Dunnington E A, White J M, Vinson W E
Genetics. 1977 Apr;85(4):659-68. doi: 10.1093/genetics/85.4.659.
Heritabilities (h2) of, and phenotypic and genetic correlations among, serum cholesterol (SC), levels of physical activity, growth, and body moisture content were estimated from data on 466 sire-son pairs of random-bred, ICR albino mice. Heritability estimates of SC and body moisture content were 0.31 +/- 0.07 and 0.29 +/- 0.11, respectively. Estimates of h2 for activity measured by standard exercise wheels at 28, 49 and 70 days of age were 0.31 +/- 0.17, 0.50 +/- 0.11 and 0.27 +/- 0.14 and for weight at 21, 44 and 67 days of age, were 0.11 +/- 0.09, 0.33 +/- 0.09 and 0.42 +/- 0.08, respectively. The estimates of h2 for weight gain ranged from 0.22 +/- 0.07 to 0.27 +/- 0.08. Significant negative phenotypic correlations occurred between activity and rate of body weight gain. A negative genetic correlation of -0.70 +/- 0.11 between SC and body moisture implied that SC and percent body fat are positively correlated. Genetic correlations among SC values and activity scores and between SC values and body weight gains were near zero.
从466对随机繁殖的ICR白化小鼠父子的数据中，估算了血清胆固醇（SC）、身体活动水平、生长和身体水分含量的遗传力（h2），以及它们之间的表型和遗传相关性。SC和身体水分含量的遗传力估计值分别为0.31±0.07和0.29±0.11。在28、49和70日龄时，通过标准运动轮测量的活动的h2估计值分别为0.31±0.17、0.50±0.11和0.27±0.14；在21、44和67日龄时，体重的h2估计值分别为0.11±0.09、0.33±0.09和0.42±0.08。体重增加的h2估计值在0.22±0.07至0.27±0.08之间。活动与体重增加率之间存在显著的负表型相关性。SC与身体水分之间的负遗传相关性为-0.70±0.11，这意味着SC与体脂百分比呈正相关。SC值与活动得分之间以及SC值与体重增加之间的遗传相关性接近零。
