Weibust R S
Genetics. 1973 Feb;73(2):303-12. doi: 10.1093/genetics/73.2.303.
Mean plasma cholesterol levels were determined at two ages in mice from eight unrelated inbred strains (BALB/cJ, BDP/J, CBA/J, C57BL/6J, LP/J, RF/J, SJL/J, and 129/J). Significant strain, sex, and age differences were observed. Estimates of the degree of genetic determination of the trait obtained from an analysis of the strain data averaged 58 +/- 4% for the males and 54 +/- 8% for the females.-Selection for high and low plasma cholesterol levels produced two significantly different and distinct lines. Selection was initiated in a genetically heterogeneous population derived from an eight-way cross of the inbred strains listed above. After five generations of selection the divergence of the high and low lines amounted to 4 phenotypic standard deviations of the foundation population. Realized heritability estimated from the regression of divergence on the combined cumulative selection differential was 51 +/- 5% for the males and 50 +/- 3% for the females. The results indicate that genetic factors are important in controlling plasma cholesterol levels in the mouse and that the majority of these factors act additively.
测定了来自八个不相关近交系（BALB/cJ、BDP/J、CBA/J、C57BL/6J、LP/J、RF/J、SJL/J和129/J）小鼠在两个年龄段的平均血浆胆固醇水平。观察到显著的品系、性别和年龄差异。通过对品系数据的分析得出，该性状遗传决定程度的估计值，雄性平均为58±4%，雌性平均为54±8%。对高血浆胆固醇水平和低血浆胆固醇水平进行选择产生了两个显著不同且有区别的品系。选择始于由上述近交系的八向杂交产生的遗传异质群体。经过五代选择，高、低品系的差异达到基础群体的4个表型标准差。根据差异对综合累积选择差的回归估计，雄性的实现遗传力为51±5%，雌性为50±3%。结果表明，遗传因素在控制小鼠血浆胆固醇水平方面很重要，并且这些因素大多以加性方式起作用。
