Ando J, Kamiya A
Department of Cardiovascular Biomechanics, Faculty of Medicine, University of Tokoyo, Tokyo, Japan.
Jpn Heart J. 1996 Jan;37(1):19-32. doi: 10.1536/ihj.37.19.
Vascular endothelial cells are constantly exposed to wall shear stress generated by blood flow. Endothelial cells act as mechanoceptors sensing and responding to shear stress, and play a role in flow-dependent phenomena such as angiogenesis, vascular remodeling and atherosclerosis. Numerous recent studies have demonstrated that endothelial cell functions change in response to shear stress, and that the responses are often accompanied by changes in related gene expression. More recently there has been evidence that genes known to be regulated by shear stress may have a common cis-element (shear stress responsive element; SSRE) in their promoter regions. A molecular mechanism for endothelial cell responses to mechanical stress is close to being elucidated. In this paper, shear-stress-mediated regulation of endothelial gene expression is reviewed.
血管内皮细胞持续暴露于血流产生的壁面剪切应力。内皮细胞作为机械感受器感知并响应剪切应力，并在诸如血管生成、血管重塑和动脉粥样硬化等血流依赖性现象中发挥作用。最近的大量研究表明，内皮细胞功能会因剪切应力而改变，且这些反应通常伴随着相关基因表达的变化。最近有证据表明，已知受剪切应力调节的基因在其启动子区域可能有一个共同的顺式元件（剪切应力反应元件；SSRE）。内皮细胞对机械应力反应的分子机制已接近阐明。本文综述了剪切应力介导的内皮基因表达调控。
