Long-lasting immune response induced by recombinant bacillus Calmette-Guérin (BCG) secretion system.

作者信息

Wada N, Ohara N, Kameoka M, Nishino Y, Matsumoto S, Nishiyama T, Naito M, Yukitake H, Okada Y, Ikuta K, Yamada T

机构信息

School of Dentistry, Nagasaki University, Nagasaki City, Japan.

出版信息

Scand J Immunol. 1996 Feb;43(2):202-9. doi: 10.1046/j.1365-3083.1996.d01-28.x.

The recombinant bacillus Calmette-Guérin (rBCG) secretion system utilizing an extracellular alpha antigen of Mycobacterium kansasii (alpha-K) was characterized biochemically and immunologically. The human immunodeficiency virus type 1 (HIV-1) p17gag B cell epitope fused to alpha-K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the epitope. The long-lasting antibody production persisted more than 14 months.