有证据表明脑前列腺素合成在发热中并非必不可少。
Evidence that brain prostaglandin synthesis is not essential in fever.
作者信息
Cranston W I, Duff G W, Hellon R F, Mitchell D, Townsend Y
出版信息
J Physiol. 1976 Jul;259(1):239-49. doi: 10.1113/jphysiol.1976.sp011464.
Abstract
- We have tested the hypothesis that a fever caused by pyrogen depends upon the synthesis of prostaglandin E in the brain and that the prostaglandin in turn acts on the hypothalamus to produce fever. 2. In rabbits, fever was produced by the injection of leucocyte pyrogen in a lateral cerebral ventricle. The latency, rate of rise and magnitude of the fever was unaffected by the simultaneous intraventricular injection of two prostaglandin antagonists, SC 19220 and HR 546. 3. Both antagonists effectively attenuated the fever caused by the intraventricular injection of prostaglandin E2. 4. This evidence is not consistent with the hypothesis that prostaglandin E is the principal mediator of fever.
摘要
- 我们已经验证了这样一个假说：热原引起的发热取决于大脑中前列腺素E的合成，而前列腺素又作用于下丘脑以产生发热。2. 在兔子身上，通过向侧脑室注射白细胞热原引发发热。发热的潜伏期、上升速率和程度不受同时向脑室内注射两种前列腺素拮抗剂SC 19220和HR 546的影响。3. 两种拮抗剂均有效减轻了脑室内注射前列腺素E2所引起的发热。4. 这一证据与前列腺素E是发热的主要介质这一假说不一致。
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本文引用的文献
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