前列腺素拮抗作用对兔花生四烯酸钠发热的影响。
Effects of prostaglandin antagonism on sodium arachidonate fever in rabbits.
作者信息
Laburn H, Mitchell D, Rosendorff C
出版信息
J Physiol. 1977 May;267(2):559-70. doi: 10.1113/jphysiol.1977.sp011826.
Abstract
- Sodium arachidonate, the prostaglandin precursor substance, when injected intraventricularly into rabbits, results in dose-dependent hyperthermia, which is rapid in onset and of several hours duration. 2. Arachidonate fever was inhibited by intraventricular injection of indomethacin, but not by the simultaneous intraventricular injection of either of the two prostaglandin antagonists SC 19220 or HR 546. 3. Both antagonists effectively inhibited the fever induced by the intraventricular injection of an equipotent dose of PGE1. 4. Our results show that a derivative of arachidonic acid other than prostaglandin is pyrogenic.
摘要
- 花生四烯酸钠作为前列腺素的前体物质，当脑室内注射到兔子体内时，会导致剂量依赖性体温升高，起效迅速且持续数小时。2. 脑室内注射吲哚美辛可抑制花生四烯酸引起的发热，但同时脑室内注射两种前列腺素拮抗剂SC 19220或HR 546则不能抑制。3. 两种拮抗剂均能有效抑制脑室内注射等剂量PGE1所引起的发热。4. 我们的结果表明，除前列腺素外，花生四烯酸的一种衍生物具有致热作用。
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