Alkmin M G, Landgraf I M, Vieira M F, Camargo M C, Gonçalves M I
Seçõe de Imunologia, Instituto Adolfo Lutz, São Paulo, Brasil.
Braz J Med Biol Res. 1995 Oct;28(10):1065-8.
We compare the results obtained by counterimmunoelectrophoresis in samples of serum and cerebrospinal fluid with microbiologic methods for 3,298 patients suspected of bacterial meningitis and/or septicemia at Instituto Adolfo Lutz, São Paulo, in a retrospective study of the period from July 1998 to July 1994. Of the 415 patients (12.6% of the total cases studied) who were positive by the serum test, only 249 (7.6% of the total cases studied) were also positive when cerebrospinal fluid was assayed. Thus, 40% of the positives (5.6% of the total) were identifiable by analysis of serum but not of cerebrospinal fluid. Neisseria meningitidis accounted for 77.7% (129) and Haemophilus influenzae for 22.3% (37) of the positive results obtained only when serum was examined. These data show that although sensitivity and specificity of serum counterimmunoelectrophoresis are relatively low compared to cerebrospinal fluid counterimmunoelectrophoresis, the serum test is necessary to complement cerebrospinal fluid counterimmunoelectrophoresis data.
在圣保罗阿道夫·卢茨研究所对1994年7月至1998年7月期间疑似细菌性脑膜炎和/或败血症的3298例患者进行的回顾性研究中，我们将血清和脑脊液样本中通过对流免疫电泳获得的结果与微生物学方法进行了比较。在血清检测呈阳性的415例患者（占所研究病例总数的12.6%）中，只有249例（占所研究病例总数的7.6%）脑脊液检测也呈阳性。因此，40%的阳性病例（占总数的5.6%）通过血清分析可识别，但脑脊液分析无法识别。仅血清检测呈阳性的结果中，脑膜炎奈瑟菌占77.7%（129例），流感嗜血杆菌占22.3%（37例）。这些数据表明，尽管与脑脊液对流免疫电泳相比，血清对流免疫电泳的敏感性和特异性相对较低，但血清检测对于补充脑脊液对流免疫电泳数据是必要的。
