不同浓度和pH值的乙醇酸的临床和组织学效应。
Clinical and histological effects of glycolic acid at different concentrations and pH levels.
作者信息
DiNardo J C, Grove G L, Moy L S
机构信息
Skin Study Center, Broomall, Pennsylvania, USA.
出版信息
Dermatol Surg. 1996 May;22(5):421-4. doi: 10.1111/j.1524-4725.1996.tb00341.x.
BACKGROUND
Much has been said about the effects of glycolic acid with little scientific evidence to substantiate the findings. OBJECTIVE. This study reports on the clinical and histological effects of glycolic acid at pH levels 3.25, 3.80, and 4.40, and at 3.25%, 6.50%, 9.75%, and 13.00% on ichthyotic/xerotic skin.
METHODS
Product treatment consisted of a 2-week washout period followed by 3 weeks of product application (BID) with A 1-week regression period. Shave biopsies and clinical evaluations for dryness, moisturization, and transepidermal water loss were made at baseline, 1, 2, and 3 weeks of use, and at the regression period.
RESULTS
Clinically, ichthyotic/xerotic skin was normalized with histologic evidence of stratum corneum thinning, viable epidermal thickening, and marked increases in glycosaminoglycan and collagen content.
CONCLUSION
All pH levels and concentrations demonstrated significant improvement in the condition of the skin with trends implying that increasing the pH increases efficacy.
背景
关于乙醇酸的作用已有诸多论述，但几乎没有科学证据来证实这些发现。目的：本研究报告了pH值为3.25、3.80和4.40以及浓度为3.25%、6.50%、9.75%和13.00%的乙醇酸对鱼鳞病/干性皮肤的临床和组织学影响。
方法
产品治疗包括2周的洗脱期，随后是3周的产品应用（每日两次）以及1周的恢复期。在基线、使用1周、2周和3周以及恢复期进行剃刀活检，并对干燥、保湿和经表皮水分流失进行临床评估。
结果
临床上，鱼鳞病/干性皮肤恢复正常，组织学证据显示角质层变薄、有活力的表皮增厚，糖胺聚糖和胶原蛋白含量显著增加。
结论
所有pH值水平和浓度均显示皮肤状况有显著改善，趋势表明提高pH值可增强疗效。
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