Bernstein E F, Lee J, Brown D B, Yu R, Van Scott E
DakDak Photoaging Technologies, Wynnewood, Pennsylvania, Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Dermatol Surg. 2001 May;27(5):429-33. doi: 10.1046/j.1524-4725.2001.00234.x.
Chronic solar irradiation results in both morphologic and functional changes in affected skin. alpha-hydroxy acids, such as glycolic acid, have been shown to improve photodamaged skin.
To investigate alterations in collagen gene induction and epidermal and dermal hyaluronic acid production as a result of administered glycolic acid.
In this study we compared collagen gene expression from skin biopsy specimens, and epidermal and dermal hyaluronic acid immunohistochemical staining between glycolic acid-treated and vehicle-treated skin. Forearm skin was treated with 20% glycolic acid lotion or a lotion vehicle control twice a day for 3 months.
Epidermal and dermal hyaluronic acid and collagen gene expression were all increased in glycolic acid-treated skin as compared to vehicle-treated controls.
Our data suggest that epidermal and dermal remodeling of the extracellular matrix results from glycolic acid treatment. Longer treatment intervals may result in collagen deposition as suggested by the measured increase in mRNA.
长期日光照射会导致受影响皮肤出现形态和功能变化。α-羟基酸，如乙醇酸，已被证明可改善光损伤皮肤。
研究外用乙醇酸后胶原基因诱导以及表皮和真皮透明质酸生成的变化。
在本研究中，我们比较了乙醇酸治疗组和赋形剂治疗组皮肤活检标本的胶原基因表达以及表皮和真皮透明质酸免疫组化染色情况。前臂皮肤每天用20%乙醇酸洗剂或洗剂赋形剂对照处理两次，持续3个月。
与赋形剂治疗的对照组相比，乙醇酸治疗的皮肤中表皮和真皮透明质酸以及胶原基因表达均增加。
我们的数据表明，乙醇酸治疗可导致细胞外基质的表皮和真皮重塑。如mRNA测量增加所示，更长的治疗间隔可能会导致胶原沉积。
