Becker B, Shin D H
Int Arch Allergy Appl Immunol. 1977;54(2):187-90. doi: 10.1159/000231824.
The prevalences of HLA-A 3, BW 35, B 7 and B 12 in 80 Caucasian patients with ocular hypertension were intermediate between values found in ocular normotensives and in patients with primary open-angle glaucoma. The presence of HLA-B 7 or B 12 had significant predictive value for the development of glaucomatous damage to the optic nerve in patients with ocular hypertension. The HLA-A 3 antigen by itself, or in combination with B 7 and B 12 did not improve the prognostic value of the B 7 and B 12 antigens. Only one of the 20 white ocular hypertensives in this series with HLA BW 35 antigen developed glaucomatous visual field loss.
80例白种人高眼压症患者中，HLA - A3、BW35、B7和B12的患病率介于眼压正常者和原发性开角型青光眼患者的相应数值之间。HLA - B7或B12的存在对高眼压症患者视神经发生青光眼性损害具有显著的预测价值。HLA - A3抗原单独或与B7和B12联合，均不能提高B7和B12抗原的预后价值。在该系列中，20例携带HLA BW35抗原的白人高眼压症患者中只有1例出现青光眼性视野缺损。
