Shin D H, Becker B, Bell C E
Int Arch Allergy Appl Immunol. 1977;55(1-6):546-50. doi: 10.1159/000231970.
Histocompatibility antigen typing was carried out in 50 Caucasian patients with primary open-angle glaucoma (POAG) and 50 Caucasian ocular-normotensive subjects. HLA-A 3 was present in 46%, B7 in 52%, B12 in 50%, and either B7 or B12 in 88% of p,tients with POAG. These prevalences in POAG patients were significantly greater than in ocular-normotensive subjects (p less than 0.01, p less than 0.0005, p less than 0.001, and p less than less than 0.0005, respectively). The prevalences of A 3-B 7, A 3-B 12 and either combination were also significantly greater in POAG patients than in the ocular normotensives (p less than 0.005, p less than 0.005, and p less than 0.0005, respectively). HLA-BW 35 was noted to be in deficit in Caucasian POAG patients (8%) as compared to Caucasian ocular normotensives (32%; p less than 0.01).
对50例白人原发性开角型青光眼（POAG）患者和50例白人眼压正常者进行了组织相容性抗原分型。在POAG患者中，HLA - A3的出现率为46%，B7为52%，B12为50%，88%的POAG患者出现B7或B12。POAG患者中这些抗原的出现率显著高于眼压正常者（分别为p<0.01、p<0.0005、p<0.001和p<<0.0005）。POAG患者中A3 - B7、A3 - B12及其任一组合的出现率也显著高于眼压正常者（分别为p<0.005、p<0.005和p<0.0005）。与白人眼压正常者（32%）相比，白人POAG患者中HLA - BW35出现率较低（8%；p<0.01）。
