Shin D H, Becker B
Am J Ophthalmol. 1976 Dec;82(6):871-4. doi: 10.1016/0002-9394(76)90063-5.
The presence of the histocompatibility antigens HLA-B12 or HLA-B7 in 76 patients with increased intraocular pressure and a GG response to topical corticosteroids (intraocular pressure over 31 mm Hg after six weeks of topical 0.1% dexamethasone eyedrops, four times daily) correlated with the development of glaucomatous visual field loss. In close agreement with prevalences in patients with primary open-angle glaucoma, 14 (88%) of the 16 patients with increased intraocular pressure and a GG response who developed glaucomatous visual field loss had either HLA-B12 or B7 antigens. Fourteen (41%) of 34 patients with increased intraocular pressure and a GG response who had B12 or B7 antigens developed glaucomatous visual field loss but only two (5%) of 42 similar patients without either antigen had visual field loss. Other factors such as the initial intraocular pressure, the horizontal cup/disk ratio, and family history of glaucoma proved less valuable as prognostic indicators in this series.
76例眼压升高且对局部皮质类固醇呈GG反应（每日4次局部使用0.1%地塞米松滴眼液6周后眼压超过31 mmHg）的患者中，组织相容性抗原HLA - B12或HLA - B7的存在与青光眼性视野缺损的发生相关。与原发性开角型青光眼患者的患病率密切一致，16例眼压升高且呈GG反应并发生青光眼性视野缺损的患者中，有14例（88%）具有HLA - B12或B7抗原。34例眼压升高且呈GG反应并具有B12或B7抗原的患者中，有14例（41%）发生了青光眼性视野缺损，但42例无任何一种抗原的类似患者中只有2例（5%）出现视野缺损。在本系列研究中，其他因素如初始眼压、水平杯盘比和青光眼家族史作为预后指标的价值较低。
