Shimizu J, Oda M, Hayashi Y, Nonomura A, Watanabe Y
Department of Surgery, Kanazawa University School of Medicine, Japan.
Chest. 1996 Apr;109(4):989-94. doi: 10.1378/chest.109.4.989.
Adenosquamous carcinoma of the lung is an uncommon form of the lung cancer. Owing to the infrequent occurrence of this disease, no series reported to date (and to our knowledge) has been of adequate size for definitive statistical analysis. In this study, survival curves and background factors affecting prognosis in those with resected adenosquamous carcinoma of the lung were reviewed. In the period from 1973 to 1994, a total of 1,284 patients with primary lung cancer, including 44 cases (3.4%) of adenosquamous carcinoma, were surgically treated in our department. The cumulative 5-year postoperative survival rate, for all cases of adenosquamous carcinoma of the lung was 18.5%. When the survival rates were compared by histologic type, the outcomes of patients with adenosquamous carcinoma were statistically worse than for patients with squamous cell carcinoma and adenocarcinoma, owing to the highly aggressive pathologic stage of adenosquamous carcinoma. The background factors most closely associated with the survival rate in those with adenosquamous carcinoma, using Cox's proportional hazard model, were gender and the degree of nodal involvement. Five-year survival was obtained in seven patients as follows: T1N0M0 in one patient, T2N0M0 in three, T2N1M0 in two, and T3N0M0 in one. Of these seven patients, all had received complete resections, and five were N0 cases. Although our series is small, this study suggest that adenosquamous carcinoma of the lung is an aggressive tumor that grows rapidly.
肺腺鳞癌是肺癌的一种罕见形式。由于这种疾病发病率低，迄今为止（据我们所知）尚无足够规模的系列报道可供进行确定性的统计分析。在本研究中，我们回顾了肺腺鳞癌切除患者的生存曲线及影响预后的背景因素。1973年至1994年期间，我科共手术治疗了1284例原发性肺癌患者，其中包括44例（3.4%）肺腺鳞癌患者。肺腺鳞癌所有病例的累计5年术后生存率为18.5%。按组织学类型比较生存率时，由于肺腺鳞癌病理分期侵袭性高，腺鳞癌患者的预后在统计学上比鳞状细胞癌和腺癌患者更差。使用Cox比例风险模型分析，与肺腺鳞癌患者生存率密切相关的背景因素是性别和淋巴结受累程度。7例患者获得了5年生存，情况如下：1例为T1N0M0，3例为T2N0M0，2例为T2N1M0，1例为T3N0M0。这7例患者均接受了完整切除，其中5例为N0病例。尽管我们的系列病例数较少，但本研究表明肺腺鳞癌是一种生长迅速的侵袭性肿瘤。
