肾上腺素在高、低皮质类固醇反应者中的眼压降低作用。

The ocular hypotensive effect of epinephrine in high and low corticosteroid responders.

作者信息

Kass M A, Shin D H, Cooper D G, Becker B

出版信息

Invest Ophthalmol Vis Sci. 1977 Jun;16(6):530-1.

Abstract

Nonglaucomatous individuals were classified by their intraocular pressure response to 6 weeks of topical dexamethasone, 0.1%, four times daily. Twenty GG responders (over 31 mm. Hg after dexamethasone) and 20 NN responders (below 20 mm. Hg after dexamethasone) of similar age, sex, race, initial intraocular pressure, and facility of outflow were selected. After 24 hr. of treatment (two doses) with 1% epinephrine HCl, the GG subjects demonstrated a mean (+/-sigma) corrected decrease in intraocular pressure of 4.2 mm. Hg (+/- 2.5) as opposed to 1.8 mm. Hg (+/- 2.1) in the NN subjects (p less than 0.005). The relationship between increased responsiveness to corticosteroids, to epinephrine, and to theophylline suggested cyclic nucleotides as a possible common pathway.

摘要

非青光眼患者根据其对0.1%地塞米松滴眼液每日4次、持续6周的眼压反应进行分类。选择了年龄、性别、种族、初始眼压和房水流畅度相似的20名GG反应者（地塞米松治疗后眼压超过31 mmHg）和20名NN反应者（地塞米松治疗后眼压低于20 mmHg）。在用1%盐酸肾上腺素治疗24小时（两剂）后，GG组受试者的眼压平均校正降低4.2 mmHg（±2.5），而NN组受试者为1.8 mmHg（±2.1）（p<0.005）。对皮质类固醇、肾上腺素和茶碱反应性增加之间的关系表明环核苷酸可能是一条共同途径。