Shin D H, Kass M A, Becker B
Arch Ophthalmol. 1978 Jun;96(6):1012-3. doi: 10.1001/archopht.1978.03910050536007.
Twenty high responders to topical corticosteroids (intraocular pressure greater than 31 mm Hg after six weeks of topical 0.1% dexamethasone, four times daily) and 20 low responders (IOP less than 20 mm Hg) of similar age, sex, race, initial IOP, and facility of outflow were selected. After 24 hours of treatment (two doses) of topical 1% epinephrine hydrochloride, the high corticosteroid responders showed a mean (+/-SD) corrected decrease in IOP of 3.6 +/- 2.0 mm Hg as opposed to 1.8 +/- 2.1 mm Hg in the low corticosteroid responders. Within both corticosteroid groups, individuals with the antigen HLA-B12 showed significantly greater decreases in IOP. This suggested that the presence of HLA-B12 was not only associated with increased responses to corticosteroids but also to epinephrine.
选取了20名对局部用皮质类固醇激素反应高的患者（每天4次局部使用0.1%地塞米松6周后眼压大于31 mmHg）和20名反应低的患者（眼压低于20 mmHg），这些患者年龄、性别、种族、初始眼压及房水流出功能相似。在局部使用1%盐酸肾上腺素治疗24小时（两剂）后，皮质类固醇激素反应高的患者眼压平均（±标准差）校正降低3.6±2.0 mmHg，而皮质类固醇激素反应低的患者为1.8±2.1 mmHg。在两个皮质类固醇激素组中，携带抗原HLA - B12的个体眼压降低幅度明显更大。这表明HLA - B12的存在不仅与对皮质类固醇激素的反应增强有关，还与对肾上腺素的反应有关。
