Andersson J E
Psykiatrisk afdeling Y, Amtssygehuset i Herlev.
Ugeskr Laeger. 1996 Feb 12;158(7):898-901.
Wernicke's encephalopathy (WE) is a neuropsychiatric disorder caused by thiamine (vitamin B1)-deficiency. WE is most commonly seen among patients with alcohol abuse, and thiamine deficiency is here caused by several factors, among others inadequate diet, insufficient gastrointestinal absorption and enzymatic abnormalities. The syndrome, however, is also seen among non-alcoholic, undernourished patients, e.g. certain patients with cancer or AIDS. The diagnosis WE has traditionally been given when the triad of confusion, ataxia and ophthalmoplegia was present. However, it should be recognised, that these three symptoms are not always present at the same time, partly because the mental symptoms often dominate and cloud, possible ocular abnormalities and ataxia. The syndrome is, according to the author's opinion, still underdiagnosed. The treatment of WE, consisting of large doses of intravenous thiamine, is effective and safe, and therefore it is important to be aware of WE among risk-patients, especially among patients with alcohol abuse, and to institute treatment with intravenous thiamine at the slightest suspicion.
韦尼克脑病（WE）是一种由硫胺素（维生素B1）缺乏引起的神经精神障碍。WE最常见于酗酒患者，硫胺素缺乏在此由多种因素导致，包括饮食不足、胃肠道吸收不足和酶异常等。然而，该综合征也见于非酒精性营养不良患者，如某些癌症或艾滋病患者。传统上，当出现意识模糊、共济失调和眼肌麻痹三联征时才诊断为WE。然而，应该认识到，这三种症状并不总是同时出现，部分原因是精神症状往往占主导并掩盖了可能存在的眼部异常和共济失调。据作者认为，该综合征仍未得到充分诊断。WE的治疗包括大剂量静脉注射硫胺素，有效且安全，因此，认识到高危患者尤其是酗酒患者中存在WE，并在稍有怀疑时就开始静脉注射硫胺素治疗非常重要。
