Raasveld M H, Romijn J A
Afd. Inwendige Geneeskunde. Academisch Medisch Centrum, Amsterdam.
Ned Tijdschr Geneeskd. 1997 Dec 27;141(52):2537-9.
Two patients, women of 85 and 76 years, presented with horizontal ocular paresis. The first patient had a palliative ileocecal resection for adenocarcinoma with metastases and developed the ocular paresis only after intravenous glucose infusion. The second had chronic haemolytic anaemia and weight loss due to malnutrition. The two women were also confused. In both patients acute Wernicke's encephalopathy was diagnosed, caused by thiamine deficiency. The disorder could easily have been missed because of confounding clinical problems. Early treatment of Wernicke's encephalopathy (thiamine 100 mg/day intramuscularly for 3 days) is of major importance in preventing permanent neurological damage or even death.
两名患者,分别为85岁和76岁的女性,出现了水平性眼肌麻痹。第一名患者因腺癌伴转移接受了姑息性回盲部切除术,仅在静脉输注葡萄糖后出现眼肌麻痹。第二名患者患有慢性溶血性贫血,因营养不良导致体重减轻。这两名女性还伴有意识模糊。两名患者均被诊断为急性韦尼克脑病,由硫胺素缺乏引起。由于存在复杂的临床问题,这种疾病很容易被漏诊。早期治疗韦尼克脑病(硫胺素100毫克/天,肌肉注射3天)对于预防永久性神经损伤甚至死亡至关重要。