Tsubota K, Hata S, Okusawa Y, Egami F, Ohtsuki T, Nakamori K
Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
Arch Ophthalmol. 1996 Jun;114(6):715-20. doi: 10.1001/archopht.1996.01100130707012.
To study patterns of eye blinking in normal subjects and patients with dry eye.
We developed an automated, noninvasive blink monitor that permits quantitative analysis of 6 parameters of blinking. We used this method under normal conditions and then examined the effects on the patterns of blinking in patients with dry eye; several steps in this method were designed to exacerbate or ameliorate ocular surface desiccation.
The mean (+/-SD), maximum, and coefficient of variation of the interblinking time in normal subjects and patients with dry eye were 4.0 +/- 2.0 and 1.5 +/- 0.9 seconds, 8.9 +/- 4.0 and 4.2 +/- 2.4 seconds, and 55% +/- 21% and 65% +/- 24%, respectively. Those values for the blinking time were 0.20 +/- 0.04 and 0.27 +/- 0.16 seconds, 0.35 +/- 0.12 and 0.99 +/- 1.30 seconds, and 23% +/- 9% and 46% +/- 34%, respectively. The use of artificial tears or spectacles with moist panels and moist inserts tended to normalize the patterns of blinking in the patients with dry eye, whereas exposure to wind made them more abnormal.
Our technique permitted a rigorous analysis of blinking that was previously unavailable. We have shown that local ocular surface conditions alone can significantly affect patterns of blinking. This method should be applicable to studying psychologic and any other factors that may influence blinking.
研究正常受试者和干眼患者的眨眼模式。
我们开发了一种自动化、非侵入性的眨眼监测仪，可对眨眼的6个参数进行定量分析。我们在正常条件下使用该方法，然后检查其对干眼患者眨眼模式的影响；该方法中的几个步骤旨在加剧或改善眼表干燥。
正常受试者和干眼患者的平均（±标准差）、最大眨眼间隔时间及变异系数分别为4.0±2.0和1.5±0.9秒、8.9±4.0和4.2±2.4秒、55%±21%和65%±24%。眨眼时间的相应值分别为0.20±0.04和0.27±0.16秒、0.35±0.12和0.99±1.30秒、23%±9%和46%±34%。使用人工泪液或带有湿润面板及湿润插入物的眼镜往往能使干眼患者的眨眼模式恢复正常，而暴露在风中则会使其更不正常。
我们的技术允许对眨眼进行严格分析，这在以前是无法做到的。我们已经表明，仅局部眼表状况就能显著影响眨眼模式。该方法应适用于研究可能影响眨眼的心理及任何其他因素。
