Petriček Igor, Lešin Gaćina Dina, Tomić Martina, Bulum Tomislav, Bešlić Iva, Vidas Pauk Sania
Department of Ophthalmology, Zagreb University Hospital Center, 10000 Zagreb, Croatia.
School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
J Clin Med. 2024 Apr 24;13(9):2473. doi: 10.3390/jcm13092473.
: Dry eye disease (DED) stands out as one of the most common eye conditions encountered in clinical settings. This study aimed to determine the diagnostic ability and feasibility of post-blink blur time (PBBT) in detecting patients with DED symptoms. : The study included 200 subjects, 100 with and 100 without DED symptoms defined by the Schein questionnaire, who underwent assessment of DED signs [visual acuity, PBBT, conjunctival hyperemia, lid-parallel conjunctival folds-LIPCOF, tear film break-up time-TBUT, fluorescein corneal staining, and meibum score]. : DED subjects had a lower PBBT than controls ( < 0.001), with subjective (6 (1-45) s vs. 8 (1-70) s) and objective (6 (2-33) s vs. 8 (2-50) s) PBBT measurements being similar between repeats. The correlations between subjective and objective PBBT measurements were significantly positive (R = 0.873, < 0.001). Subjective PBBT was negatively related to the Schein questionnaire (R = -0.217, = 0.002), conjunctival hyperemia (R = -0.105, = 0.035), and corneal staining (R = -0.153, = 0.031), while positively related to the TBUT (R = 0.382, < 0.001) and meibum score (R = 0.106, = 0.033). Logistic regression analysis showed DED symptoms were significantly associated with subjective PBBT (AOR 0.91, = 0.001), TBUT (AOR 0.79, < 0.001), meibum score (AOR 0.65, = 0.008), LIPCOF (AOR 1.18, = 0.002) and corneal staining (AOR 1.14, = 0.028). : Subjective self-reported PBBT is a reliable and non-invasive screening test for evaluating time-wise changes in visual acuity and detecting a tear film dysfunction.
干眼症（DED）是临床环境中最常见的眼部疾病之一。本研究旨在确定眨眼后模糊时间（PBBT）在检测有DED症状患者方面的诊断能力和可行性。
该研究纳入了200名受试者，其中100名有Schein问卷定义的DED症状，100名没有，所有受试者均接受了DED体征评估[视力、PBBT、结膜充血、睑结膜平行皱襞-LIPCOF、泪膜破裂时间-TBUT、荧光素角膜染色和睑板腺评分]。
DED受试者的PBBT低于对照组（<0.001），主观（6（1-45）秒对8（1-70）秒）和客观（6（2-33）秒对8（2-50）秒）PBBT测量值在重复测量之间相似。主观和客观PBBT测量值之间的相关性显著为正（R = 0.873，<0.001）。主观PBBT与Schein问卷（R = -0.217，= 0.002）、结膜充血（R = -0.105，= 0.035）和角膜染色（R = -0.153，= 0.031）呈负相关，而与TBUT（R = 0.382，<0.001）和睑板腺评分（R = 0.106，= 0.033）呈正相关。逻辑回归分析显示，DED症状与主观PBBT（比值比0.91，= 0.001）、TBUT（比值比0.79，<0.001）、睑板腺评分（比值比0.65，= 0.008）、LIPCOF（比值比1.18，= 0.002）和角膜染色（比值比1.14，= 0.028）显著相关。
主观自我报告的PBBT是一种可靠且非侵入性的筛查测试，用于评估视力随时间的变化并检测泪膜功能障碍。
