Kowdley K V, Fawaz K A, Kaplan M M
Department of Medicine, New England Medical Center, Boston, MA, USA.
Transpl Int. 1996;9(2):161-3. doi: 10.1007/BF00336395.
We describe a patient who developed a stricture in the distal common bile duct 6 weeks after orthotopic liver transplantation. Histopathologic examination of the bile duct epithelium in the region of the stricture showed characteristic cytomegalovirus (CMV) inclusions. CMV was also identified in pulmonary alveoli and in the duodenum. Although CMV has been demonstrated in the biliary epithelium of AIDS patients with extrahepatic biliary strictures and biliary obstruction, this entity has not, to our knowledge, been described in liver transplant recipients. This report confirms that CMV infection should be included as a probable cause of extrahepatic biliary strictures and bile duct obstruction in liver transplant patients.
我们描述了一名在原位肝移植术后6周出现胆总管远端狭窄的患者。对狭窄部位胆管上皮的组织病理学检查显示有特征性的巨细胞病毒（CMV）包涵体。在肺泡和十二指肠中也发现了CMV。尽管在患有肝外胆管狭窄和胆管梗阻的艾滋病患者的胆管上皮中已证实有CMV感染，但据我们所知，在肝移植受者中尚未描述过这种情况。本报告证实，CMV感染应被列为肝移植患者肝外胆管狭窄和胆管梗阻的可能原因之一。
