Chyrek-Borowska S, Rogalewska A, Szymański W, Złotnik I, Michalska I
Kliniki Alergologii Akademii Medycznej w Białymstoku.
Pneumonol Alergol Pol. 1995;63 Suppl 2:32-41.
The aim of this study was to evaluate the efficacy, tolerance and immunogenity of allergenic extracts: Allergovit and Novo-Hellisen depot (produced by Allergopharma--Germany), used for sIT in pollinosis and house dust mite allergy. The treatment was carried out on 40 patients for three years. The evaluation included the results of a physical examination, the score of symptoms from self-observations and the consumption of antiallergic medicines. In addition to the serum IgE and IgG4 the percentage of histamine, liberated by a-IgE and specific allergens, from peripheral blood basophils was determined. In some of patients treated with Novo-Helisen depot the specific and nonspecific bronchial challenge tests were made. It was shown that the allergenic extracts Allergovit and Novo-Helisen depot are effective in treatment of pollinosis and house dust mite allergy, and are well tolerated by the patients. The changes in humoral response during sIT manifest their immunogenity. The sIT with Allergovit decreases the sensitivity of the peripheral blood basophils, whereas the treatment with Novo-Helisen depot causes a diminution of bronchial specific and nonspecific reactivity and a negativisation of late allergic reaction.
本研究的目的是评估变应原提取物Allergovit和Novo-Hellisen长效注射剂（由德国Allergopharma生产）用于花粉症和屋尘螨过敏的特异性免疫治疗（sIT）时的疗效、耐受性和免疫原性。对40例患者进行了为期三年的治疗。评估包括体格检查结果、自我观察的症状评分以及抗过敏药物的使用情况。除了血清IgE和IgG4外，还测定了α-IgE和特异性变应原从外周血嗜碱性粒细胞释放的组胺百分比。在一些接受Novo-Hellisen长效注射剂治疗的患者中进行了特异性和非特异性支气管激发试验。结果表明，变应原提取物Allergovit和Novo-Hellisen长效注射剂对花粉症和屋尘螨过敏有效，且患者耐受性良好。sIT期间体液反应的变化体现了其免疫原性。Allergovit进行的sIT降低了外周血嗜碱性粒细胞的敏感性，而Novo-Hellisen长效注射剂治疗则导致支气管特异性和非特异性反应性降低以及迟发性过敏反应转阴。
