复发性转移性纤维板层型肝细胞癌复杂核型报告及肝细胞癌细胞遗传学综述
Report of a complex karyotype in recurrent metastatic fibrolamellar hepatocellular carcinoma and a review of hepatocellular carcinoma cytogenetics.
作者信息
Lowichik A, Schneider N R, Tonk V, Ansari M Q, Timmons C F
机构信息
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, USA.
出版信息
Cancer Genet Cytogenet. 1996 Jun;88(2):170-4. doi: 10.1016/0165-4608(95)00314-2.
Metastatic fibrolamellar hepatocellular carcinoma (HCC) was detected in the abdominal lymph nodes of an adolescent male after resection of the primary tumor. No dividing cells were isolated from attempted cytogenetic studies of the primary tumor. However, cytogenetic analysis of lymph node metastases detected 9 and 12 months after partial hepatectomy revealed abnormal hypertriploid karyotypes, with a suggestion of clonal evolution: 62-92 < 3n >,XX, -Y, +3, +6, +6, +7, +7, +8, +10, +13, +15, +16, +20, -21, -22, +mar1 x 2, +mar[cp6]/46,XY[8] and 78 < 3n >,XX, -Y,der(1)t(1;1)(p36.1;q21), +4, +6, +6, +7, +7,i(8)(q10), +10, +15, +20, -21, -22, +mar1 x 2, +mar2[3]/46, XY[17], respectively. Karyotypes of this variant of HCC have not been reported previously. The cytogenetics of HCC are reviewed.
在一名青少年男性原发性肿瘤切除后，其腹部淋巴结中检测到转移性纤维板层型肝细胞癌（HCC）。对原发性肿瘤进行细胞遗传学研究时未分离出分裂细胞。然而，对部分肝切除术后9个月和12个月检测到的淋巴结转移灶进行细胞遗传学分析发现，存在异常的超三倍体核型，提示有克隆进化：分别为62 - 92 < 3n >,XX, -Y, +3, +6, +6, +7, +7, +8, +10, +13, +15, +16, +20, -21, -22, +mar1 x 2, +mar[cp6]/46,XY[8]和78 < 3n >,XX, -Y,der(1)t(1;1)(p36.1;q21), +4, +6, +6, +7, +7,i(8)(q10), +10, +15, +20, -21, -22, +mar1 x 2, +mar2[3]/46, XY[17]。此前尚未报道过这种HCC变体的核型。本文对HCC的细胞遗传学进行了综述。
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