Bardi G, Johansson B, Pandis N, Heim S, Mandahl N, Andrén-Sandberg A, Hägerstrand I, Mitelman F
Department of Clinical Genetics, Lund University Hospital, Sweden.
Cancer Genet Cytogenet. 1992 Feb;58(2):191-5. doi: 10.1016/0165-4608(92)90111-k.
Short-term cultures of three primary hepatocellular carcinomas were cytogenetically analyzed. Case 1 displayed a normal karyotype. Case 2 had, in addition to cells with a normal male chromosome complement, a clone with -Y. In case 3, two abnormal clones were found, one with -Y and one with a highly aberrant karyotype: [formula: see text] Our results, collated with the findings in one previously published primary hepatocellular carcinoma and in three cell lines, suggest that structural changes of chromosomes 1 and 6, leading to loss of 1p and 6q material, and loss of chromosome 16 are frequent events in hepatocellular carcinogenesis.
对三个原发性肝细胞癌的短期培养物进行了细胞遗传学分析。病例1显示核型正常。病例2除了具有正常男性染色体组成的细胞外，还有一个带有-Y的克隆。在病例3中，发现了两个异常克隆，一个带有-Y，另一个具有高度异常的核型：[公式：见正文]我们的结果与之前发表的一例原发性肝细胞癌和三个细胞系中的发现相结合，表明1号和6号染色体的结构变化导致1p和6q物质的缺失以及16号染色体的缺失是肝细胞癌发生过程中的常见事件。
