在X射线诱导的CD（SD）大鼠胃肠化生背景下，1,2 - 二甲基肼的胃癌致瘤性。
Gastric tumorigenicity of 1,2-dimethylhydrazine on the background of gastric intestinal metaplasia induced by X-irradiation in CD (SD) rats.
作者信息
Ando Y, Watanabe H, Tatematsu M, Hirano K, Furihata C, Fujimoto N, Toge T, Ito A
机构信息
Department of Cancer Research, Hiroshima University, Japan.
出版信息
Jpn J Cancer Res. 1996 May;87(5):433-6. doi: 10.1111/j.1349-7006.1996.tb00242.x.
Five-week-old male CD (SD) rats were X-irradiated with a total of 20 Gy in 2 equal fractions with a 3-day interval. After the second irradiation, rats were fed normal diet supplemented with 1% sodium chloride, which is known to increase intestinal metaplasia. 1,2-Dimethylhydrazine (DMH) solution was injected i.m. into the back musculature at a dose of 20 mg/kg body weight weekly for 10 weeks, beginning 20 weeks after the final irradiation. Twelve months after the initial carcinogen treatment, gastric tumors in the glandular stomach were observed in 2 (3 lesions) of 30 animals in the X-irradiated and DMH-treated group fed diet supplemented with 1% sodium chloride. No gastric tumors were observed in the group which excluded X-irradiation from the experimental protocol.
5周龄雄性CD（SD）大鼠接受X射线照射，分2次等量给予，每次10 Gy，间隔3天。第二次照射后，给大鼠喂食添加1%氯化钠的正常饮食，已知该物质会增加肠化生。从最后一次照射后20周开始，每周一次肌肉注射1,2 - 二甲基肼（DMH）溶液，剂量为20 mg/kg体重，持续10周。在初始致癌物处理12个月后，在喂食添加1%氯化钠饮食的X射线照射及DMH处理组的30只动物中，有2只（3处病变）在腺胃中观察到胃肿瘤。在实验方案中排除X射线照射的组未观察到胃肿瘤。
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