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[儿童接触受污染土壤中的铅]

[Exposure of children to lead from contaminated soil].

作者信息

Jacobsen P

机构信息

Arbejdsmedicinsk klinik, Rigshospitalet, København.

出版信息

Ugeskr Laeger. 1996 Mar 11;158(11):1499-502.

PMID:8644394
Abstract

To assess lead exposure in infants from contaminated soil a review of epidemiological studies was performed. Seventeen studies fulfilled criteria of individual exposure measures and a relevant confounder control. In 10 of these a clear association between blood lead and lead in soil was demonstrated after control of confounders. With some reservations three additional studies indicated an effect. No effect on blood lead from soil exposure was found in four studies. Quantitative estimates of the contributions to blood lead from soil varied within a wide range. In the best designed study-a controlled intervention against contaminated soil-blood lead values declined a little more than 1 microgram/100 ml per 1000 ppm. reduction of soil lead concentration. Oral exposure, probably by mouthing behaviour, was indicated by modification of the association between blood and soil lead from time spent outdoors, area with uncovered soil, age and mouthing behaviour in several studies. The conclusions from the review were that children's mouthing behaviour on lead contaminated soil may affect blood lead, but the contribution to overall lead exposure seems to be relatively small. Considering the limited margin of safety for lead exposure an intervention regimen for contaminated areas where infants have direct and continued contact with soil is suggested. Intervention in other places is unlikely to significantly reduce the lead burden of children. Simultaneously with intervention a programme for the evaluation of its effect is proposed.

摘要

为评估受污染土壤对婴儿铅暴露的影响,我们对流行病学研究进行了综述。17项研究符合个体暴露测量和相关混杂因素控制的标准。其中10项研究在控制混杂因素后表明血铅与土壤铅之间存在明确关联。另有3项研究在有一定保留意见的情况下表明存在影响。4项研究未发现土壤暴露对血铅有影响。土壤对血铅贡献的定量估计范围很广。在设计最佳的研究——一项针对受污染土壤的对照干预研究中,土壤铅浓度每降低1000 ppm,血铅值下降略超过1微克/100毫升。几项研究通过户外时间、未覆盖土壤的区域、年龄和口咬行为对血铅与土壤铅之间的关联进行修正,表明可能是通过口咬行为导致经口暴露。综述得出的结论是,儿童在受铅污染土壤上的口咬行为可能会影响血铅,但对总体铅暴露的贡献似乎相对较小。考虑到铅暴露的安全边际有限,建议针对婴儿与土壤有直接持续接触的污染区域制定干预方案。在其他地方进行干预不太可能显著降低儿童的铅负荷。在进行干预的同时,提出一项评估其效果的方案。

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