细菌性脑膜炎患儿脑脊液中的白细胞介素-10和可溶性肿瘤坏死因子受体

Interleukin-10 and soluble tumor necrosis factor receptors in cerebrospinal fluid of children with bacterial meningitis.

作者信息

Kornelisse R F, Savelkoul H F, Mulder P H, Suur M H, van der Straaten P J, van der Heijden A J, Sukhai R N, Hählen K, Neijens H J, de Groot R

机构信息

Department of Pediatrics, Sophia Children's Hospital/University Hospital, Rotterdam, Netherlands.

出版信息

J Infect Dis. 1996 Jun;173(6):1498-502. doi: 10.1093/infdis/173.6.1498.

DOI:10.1093/infdis/173.6.1498

PMID:8648229

Abstract

The antiinflammatory mediators interleukin (IL)-10 and soluble tumor necrosis factor (TNF) receptors p55 (sTNFR-55) and sTNFR-75 in cerebrospinal fluid (CSF) from 37 children with bacterial meningitis were studied. CSF concentrations of IL-10, sTNFR-55, and sTNFR-75 and of the proinflammatory cytokines TNF-alpha, IL-6, and IL-8 were markedly elevated and were, with the exception of the sTNFRs, significantly higher in CSF than in serum. CSF concentrations of sTNFR- 55 and sTNFR-75 were only associated positively with IL-10 levels. CSF glucose levels correlated highly with levels of IL-10, sTNFR-55, and sTNFR-75 and weakly with TNF-alpha and IL-6. Cytokine levels in CSF decreased rapidly, while sTNFR levels remained elevated for at least 24 h.

摘要

对37例细菌性脑膜炎患儿脑脊液（CSF）中的抗炎介质白细胞介素（IL）-10、可溶性肿瘤坏死因子（TNF）受体p55（sTNFR-55）和sTNFR-75进行了研究。IL-10、sTNFR-55、sTNFR-75以及促炎细胞因子TNF-α、IL-6和IL-8的脑脊液浓度显著升高，除sTNFRs外，脑脊液中的这些浓度显著高于血清。sTNFR-55和sTNFR-75的脑脊液浓度仅与IL-10水平呈正相关。脑脊液葡萄糖水平与IL-10、sTNFR-55和sTNFR-75水平高度相关，与TNF-α和IL-6水平弱相关。脑脊液中的细胞因子水平迅速下降，而sTNFR水平至少在24小时内保持升高。