同源同源结构域共调节因子对转录的差异调控。
Differential control of transcription by homologous homeodomain coregulators.
作者信息
Huang C C, Herr W
机构信息
Cold Spring Harbor Laboratory, New York 11724, USA.
出版信息
Mol Cell Biol. 1996 Jun;16(6):2967-76. doi: 10.1128/MCB.16.6.2967.
Abstract
The human herpes simplex virus type 1 (HSV-1) transactivator VP16 and its homolog from bovine herpes-virus 1 (BHV-1) can each recruit the human homeodomain protein Oct-1 into a transcriptional regulatory complex. Here, we show that these two Oct-1 coregulators possess similar, if not identical, homeodomain recognition properties but possess different virus-specific cis-regulatory specificities: the HSV-1 VP-16 protein activates transcription from the HSV-1 VP16 response element, and the BHV-1 VP16 protein activates transcription from the BHV-1 VP16 response element. A distinct 3-bp segment, the D segment, lying 3' of the canonical TAATGARAT motif (where R is a purine) in the VP16 response element is responsible for the differential cis element recognition and transcriptional activation by these two homeodomain coregulators. These results demonstrate how a single homeodomain protein can direct differential transcriptional regulation by selective association with homologous homeodomain coregulators.
摘要
人类单纯疱疹病毒1型（HSV-1）反式激活因子VP16及其来自牛疱疹病毒1型（BHV-1）的同源物，均可将人类同源结构域蛋白Oct-1招募到转录调节复合物中。在此，我们表明这两种Oct-1共调节因子具有相似（即便不是完全相同）的同源结构域识别特性，但具有不同的病毒特异性顺式调节特异性：HSV-1 VP-16蛋白可激活来自HSV-1 VP16反应元件的转录，而BHV-1 VP16蛋白可激活来自BHV-1 VP16反应元件的转录。VP16反应元件中位于典型TAATGARAT基序（其中R为嘌呤）3'端的一个独特的3碱基片段，即D片段，负责这两种同源结构域共调节因子的差异性顺式元件识别和转录激活。这些结果证明了单个同源结构域蛋白如何通过与同源同源结构域共调节因子的选择性结合来指导差异性转录调控。
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本文引用的文献
1
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Genes Dev. 1993 Jan;7(1):72-83. doi: 10.1101/gad.7.1.72.
2
A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha 2 protein and the MCM1 protein.一段短的、无序的蛋白质区域介导酵母α2蛋白的同源结构域与MCM1蛋白之间的相互作用。
Cell. 1993 Jan 15;72(1):105-12. doi: 10.1016/0092-8674(93)90054-t.
3
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Cell. 1993 Jul 16;74(1):115-25. doi: 10.1016/0092-8674(93)90299-6.
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J Virol. 1993 May;67(5):2739-46. doi: 10.1128/JVI.67.5.2739-2746.1993.
5
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9
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Cell. 1994 Dec 2;79(5):841-52. doi: 10.1016/0092-8674(94)90073-6.
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Mol Cell Biol. 1995 Apr;15(4):2090-100. doi: 10.1128/MCB.15.4.2090.
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