溶菌酶完整抗原结构的精确测定：蛋白质抗原结构的分子特征及“表面模拟”合成的潜力——蛋白质结合位点的一个强大新概念 - Suppr

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Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites.

作者信息

Atassi M Z

出版信息

Immunochemistry. 1978 Dec;15(12):909-36. doi: 10.1016/0161-5890(78)90126-8.

DOI:10.1016/0161-5890(78)90126-8

PMID:86497

Abstract

摘要

相似文献

Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites.溶菌酶完整抗原结构的精确测定：蛋白质抗原结构的分子特征及“表面模拟”合成的潜力——蛋白质结合位点的一个强大新概念

Immunochemistry. 1978 Dec;15(12):909-36. doi: 10.1016/0161-5890(78)90126-8.

The precise and entire antigenic structure of lysozyme: implications of surface-simulation synthesis and the molecular features of protein antigenic sites.溶菌酶精确完整的抗原结构：表面模拟合成的意义及蛋白质抗原位点的分子特征

Adv Exp Med Biol. 1978;98:41-99. doi: 10.1007/978-1-4615-8858-0_4.

Determination of the entire antigenic structure of native lysozyme by surface-simulation synthesis, a novel concept in molecular recognition.通过表面模拟合成确定天然溶菌酶的完整抗原结构，这是分子识别中的一个新概念。

CRC Crit Rev Biochem. 1979;6(4):371-400. doi: 10.3109/10409237909105426.

Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites.蛋白质抗原结构的精确测定揭示了蛋白质的分子免疫识别，并为其他蛋白质结合位点的合成模拟提供了原型。

Mol Cell Biochem. 1980 Aug 29;32(1):21-43. doi: 10.1007/BF00421293.

Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis.通过“表面模拟”合成对围绕二硫键6-127（位点1）的溶菌酶抗原位点进行边界优化。

Biochem J. 1978 May 1;171(2):419-27. doi: 10.1042/bj1710419.

The precise and entire antigenic structure of native lysozyme.天然溶菌酶精确完整的抗原结构。

Biochem J. 1978 May 1;171(2):429-34. doi: 10.1042/bj1710429.

Enzymic and immunochemical properties of lysozyme. XVI. A novel synthetic approach to an antigenic reactive site by direct linkage of the relevant conformationally adjacent residues constituting the site.溶菌酶的酶学与免疫化学性质。十六、通过直接连接构成抗原反应位点的相关构象相邻残基来构建该位点的一种新型合成方法。

Biochim Biophys Acta. 1976 Apr 14;427(2):745-51. doi: 10.1016/0005-2795(76)90219-1.

Three distinct epitopes within the loop region of hen egg lysozyme defined with monoclonal antibodies.用单克隆抗体确定了鸡卵溶菌酶环区的三个不同表位。

EMBO J. 1985 Feb;4(2):383-92. doi: 10.1002/j.1460-2075.1985.tb03640.x.

Enzymic and immunochemical properties of lysozyme. XIX. Definition of the direction and conformational restrictions of the antigenic site around the disulfide bonds 64-80 and 76-94 (site 2) by 'surface-simulation' synthesis.溶菌酶的酶学和免疫化学性质。第十九部分。通过“表面模拟”合成确定二硫键64 - 80和76 - 94周围抗原位点（位点2）的方向和构象限制

Biochim Biophys Acta. 1977 Dec 20;495(2):354-68. doi: 10.1016/0005-2795(77)90391-9.

Chemical strategy for studying the antigenic structures of disulfide-containing proteins: hen egg-white lysozyme as a model.研究含二硫键蛋白质抗原结构的化学策略：以鸡蛋清溶菌酶为模型

Adv Exp Med Biol. 1977;86A:89-137. doi: 10.1007/978-1-4684-3282-4_6.

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Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin.肉毒杆菌神经毒素A的HN结构域上的抗原位点刺激针对活性毒素的保护性抗体反应。

Sci Rep. 2015 Oct 28;5:15776. doi: 10.1038/srep15776.

Predicting differential antigen-antibody contact regions based on solvent accessibility.基于溶剂可及性预测差异抗原-抗体接触区域

J Protein Chem. 1997 Aug;16(6):607-18. doi: 10.1023/a:1026370807586.

Design of peptide enzymes (pepzymes): surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active sites exhibit the activity and specificity of the respective enzyme.肽酶（pepzyme）的设计：模拟胰凝乳蛋白酶和胰蛋白酶活性位点的表面模拟合成肽表现出相应酶的活性和特异性。

Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8282-6. doi: 10.1073/pnas.90.17.8282.

10th International Conference on Methods in Protein Structure Analysis. September 8-13, 1994, Snowbird, Utah. Short communications and abstracts.第十届蛋白质结构分析方法国际会议。1994年9月8日至13日，犹他州雪鸟城。简短通讯与摘要。

J Protein Chem. 1994 Jul;13(5):431-543.

Haemoglobin binding with haptoglobin. Localization of the haptoglobin-binding site on the alpha-chain of human haemoglobin.血红蛋白与触珠蛋白的结合。触珠蛋白结合位点在人血红蛋白α链上的定位。

Biochem J. 1981 Aug 1;197(2):507-10. doi: 10.1042/bj1970507.

Binding with lysozyme of antibodies against surface-simulation peptides representing the lysozyme antigenic sites.针对代表溶菌酶抗原位点的表面模拟肽的抗体与溶菌酶的结合。

Biochem J. 1982 Mar 1;201(3):669-72. doi: 10.1042/bj2010669.

Diagnostic and therapeutic use of monoclonal antibodies to human tumor antigens.针对人类肿瘤抗原的单克隆抗体的诊断和治疗用途。

Med Oncol Tumor Pharmacother. 1984;1(3):143-7. doi: 10.1007/BF02934135.

Antibody combining sites can be mimicked synthetically. Surface-simulation synthesis of the phosphorylcholine-combining site of myeloma protein M-603.抗体结合位点可以通过合成来模拟。骨髓瘤蛋白M-603磷酸胆碱结合位点的表面模拟合成。

Biochem J. 1980 Jun 1;187(3):661-6. doi: 10.1042/bj1870661.

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.利用肽合成技术探测病毒抗原的表位，分辨率可达单个氨基酸水平。

Proc Natl Acad Sci U S A. 1984 Jul;81(13):3998-4002. doi: 10.1073/pnas.81.13.3998.

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