溶菌酶的酶学和免疫化学性质。第十九部分。通过“表面模拟”合成确定二硫键64 - 80和76 - 94周围抗原位点（位点2）的方向和构象限制 - Suppr

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超能文献

Enzymic and immunochemical properties of lysozyme. XIX. Definition of the direction and conformational restrictions of the antigenic site around the disulfide bonds 64-80 and 76-94 (site 2) by 'surface-simulation' synthesis.

作者信息

Lee C L, Atassi M Z

出版信息

Biochim Biophys Acta. 1977 Dec 20;495(2):354-68. doi: 10.1016/0005-2795(77)90391-9.

DOI:10.1016/0005-2795(77)90391-9

PMID:73386

Abstract

摘要

相似文献

Enzymic and immunochemical properties of lysozyme. XIX. Definition of the direction and conformational restrictions of the antigenic site around the disulfide bonds 64-80 and 76-94 (site 2) by 'surface-simulation' synthesis.溶菌酶的酶学和免疫化学性质。第十九部分。通过“表面模拟”合成确定二硫键64 - 80和76 - 94周围抗原位点（位点2）的方向和构象限制

Biochim Biophys Acta. 1977 Dec 20;495(2):354-68. doi: 10.1016/0005-2795(77)90391-9.

Enzymic and immunochemical properties of lysozyme. XI. Conformation and immunochemistry of the two-disulfide peptide and the tryptophan and lysine residues in its antigenic reactivity.溶菌酶的酶学和免疫化学性质。十一、二硫键肽的构象与免疫化学及其抗原反应性中的色氨酸和赖氨酸残基

Biochim Biophys Acta. 1975 Oct 20;405(2):464-74.

Chemical strategy for studying the antigenic structures of disulfide-containing proteins: hen egg-white lysozyme as a model.研究含二硫键蛋白质抗原结构的化学策略：以鸡蛋清溶菌酶为模型

Adv Exp Med Biol. 1977;86A:89-137. doi: 10.1007/978-1-4684-3282-4_6.

Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis.溶菌酶的酶学和免疫化学特性。通过“表面模拟”合成精确定义二硫键30-115周围的抗原位点（位点3）。

Biochem J. 1977 Dec 1;167(3):571-81. doi: 10.1042/bj1670571.

Enzymic and immunochemical properties of lysozyme. XIII. Accurate delineation of the reactive site around the disulfide 6-127 by immunochemical study of beta-propiolactone lysozyme derivative and of synthetic disulfide peptides.溶菌酶的酶学和免疫化学性质。十三。通过对β-丙内酯溶菌酶衍生物和合成二硫键肽的免疫化学研究精确描绘二硫键6-127周围的反应位点。

Biochim Biophys Acta. 1976 Feb 20;420(2):358-75. doi: 10.1016/0005-2795(76)90328-7.

Enzymic and immunochemical properties of lysozyme. X. Conformation, enzymic activity and immunochemistry of lysozyme reduced at two carboxyl groups.溶菌酶的酶学和免疫化学性质。X. 在两个羧基处还原的溶菌酶的构象、酶活性和免疫化学。

Biochim Biophys Acta. 1975 Oct 20;405(2):452-63. doi: 10.1016/0005-2795(75)90110-5.

The precise and entire antigenic structure of lysozyme: implications of surface-simulation synthesis and the molecular features of protein antigenic sites.溶菌酶精确完整的抗原结构：表面模拟合成的意义及蛋白质抗原位点的分子特征

Adv Exp Med Biol. 1978;98:41-99. doi: 10.1007/978-1-4615-8858-0_4.

Structure and antigenicity of hem egg-white lysozyme fragments. Study of the region (1-27) plus (122-129).蛋清溶菌酶片段的结构与抗原性。区域（1 - 27）加（122 - 129）的研究。

Eur J Biochem. 1974 Apr 1;43(2):363-9. doi: 10.1111/j.1432-1033.1974.tb03421.x.

Boundary refinement of the lysozyme antigenic site around the disulphide bond 6-127 (site 1) by 'surface-simulation' synthesis.通过“表面模拟”合成对围绕二硫键6-127（位点1）的溶菌酶抗原位点进行边界优化。

Biochem J. 1978 May 1;171(2):419-27. doi: 10.1042/bj1710419.

Determination of the entire antigenic structure of native lysozyme by surface-simulation synthesis, a novel concept in molecular recognition.通过表面模拟合成确定天然溶菌酶的完整抗原结构，这是分子识别中的一个新概念。

CRC Crit Rev Biochem. 1979;6(4):371-400. doi: 10.3109/10409237909105426.

引用本文的文献

Design of peptide enzymes (pepzymes): surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active sites exhibit the activity and specificity of the respective enzyme.肽酶（pepzyme）的设计：模拟胰凝乳蛋白酶和胰蛋白酶活性位点的表面模拟合成肽表现出相应酶的活性和特异性。

Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8282-6. doi: 10.1073/pnas.90.17.8282.

Haemoglobin binding with haptoglobin. Unequivocal demonstration that the beta-chains of human haemoglobin bind to haptoglobin.血红蛋白与触珠蛋白结合。明确证明人血红蛋白的β链与触珠蛋白结合。

Biochem J. 1980 Jan 1;185(1):285-7. doi: 10.1042/bj1850285.

Binding with lysozyme of antibodies against surface-simulation peptides representing the lysozyme antigenic sites.针对代表溶菌酶抗原位点的表面模拟肽的抗体与溶菌酶的结合。

Biochem J. 1982 Mar 1;201(3):669-72. doi: 10.1042/bj2010669.

Localization, synthesis, and activity of an antigenic site on influenza virus hemagglutinin.流感病毒血凝素抗原位点的定位、合成与活性

Proc Natl Acad Sci U S A. 1983 Feb;80(3):840-4. doi: 10.1073/pnas.80.3.840.

Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites.蛋白质抗原结构的精确测定揭示了蛋白质的分子免疫识别，并为其他蛋白质结合位点的合成模拟提供了原型。

Mol Cell Biochem. 1980 Aug 29;32(1):21-43. doi: 10.1007/BF00421293.

Surface-simulation synthesis of the substrate-binding site of an enzyme. Demonstration with trypsin.酶底物结合位点的表面模拟合成。以胰蛋白酶为例进行演示。

Biochem J. 1985 Mar 1;226(2):477-85. doi: 10.1042/bj2260477.

Antigen presentation of lysozyme: T-cell recognition of peptide and intact protein after priming with synthetic overlapping peptides comprising the entire protein chain.溶菌酶的抗原呈递：用包含整个蛋白质链的合成重叠肽进行致敏后，T细胞对肽和完整蛋白质的识别。

Immunology. 1985 Sep;56(1):103-12.

Site recognition by protein-primed T cells shows a non-specific peptide size requirement beyond the essential residues of the site. Demonstration by defining an immunodominant T site in myoglobin.蛋白质引发的T细胞对位点的识别显示，除了位点的必需残基外，还存在非特异性的肽大小要求。通过定义肌红蛋白中的免疫显性T细胞位点进行证明。

Biochem J. 1986 Nov 15;240(1):139-46. doi: 10.1042/bj2400139.

The precise and entire antigenic structure of native lysozyme.天然溶菌酶精确完整的抗原结构。

Biochem J. 1978 May 1;171(2):429-34. doi: 10.1042/bj1710429.

Biochem J. 1978 May 1;171(2):419-27. doi: 10.1042/bj1710419.

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