小鼠对半抗原的特异性无反应性。I. 2,4,6-三硝基苯磺酸诱导的无反应性特征。
Hapten specific unresponsiveness in mice. I. Characteristics of unresponsiveness induced by 2,4,6-trinitrobenzene sulphonic acid.
作者信息
Huchet R, Grandjon D, Davies A J
出版信息
Immunology. 1979 Mar;36(3):595-605.
Injection of mice with the chemically reactive hapten 2,4,6-trinitrobenzene sulphonic acid (TNBSA) induces a specific unresponsiveness as judged by reduction or abolition of the anti-TNP response to TNP-KLH. The normal response to a nonrelated hapten, oxazolone, bound to the same carrier (OX-KLH) is unaffected. Reduction of the anti-TNP response was also observed after TNBSA treatment, in nude mice (nu/nu) and their littermates (nu/+) challenged with TNP-POL, an antigen to which the response is thymus independent. Injection of the chemically non-reactive hapten TNP-glycyl-glycine did not induce unresponsiveness. A similar failure was observed with TNP autologous red cells or serum proteins from mice previously injected with TNBSA. The specific unresponsiveness of spleen cells of TNBSA injected mice was maintained after their transfer into lethally irradiated syngeneic host mice. Finally tolerant cells do not inhibit specifically an adoptive anti-TNP secondary response.
用化学反应性半抗原2,4,6-三硝基苯磺酸（TNBSA）注射小鼠，根据对TNP-KLH的抗TNP反应降低或消失来判断，可诱导特异性无反应性。对与相同载体结合的无关半抗原恶唑酮（OX-KLH）的正常反应不受影响。在用TNP-POL（一种对其反应不依赖胸腺的抗原）攻击的裸鼠（nu/nu）及其同窝小鼠（nu/+）中，TNBSA处理后也观察到抗TNP反应降低。注射化学性质无反应性的半抗原TNP-甘氨酰甘氨酸不会诱导无反应性。在用TNBSA预先注射的小鼠的TNP自体红细胞或血清蛋白中也观察到类似的失败情况。将注射TNBSA的小鼠的脾细胞转移到经致死性照射的同基因宿主小鼠中后，其特异性无反应性得以维持。最后，耐受细胞不会特异性抑制过继性抗TNP二次反应。
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