Hwang D F, Lai Y S, Chiang M T
Department of Marine Food Science, National Taiwan Ocean University, Keelung, R.O.C.
Toxicol Lett. 1996 May;85(2):85-92. doi: 10.1016/0378-4274(96)03644-2.
To evaluate the toxic effects of different animal bile juices, male Long-Evans rats were used and treated orally with different doses (0.03-0.6 ml) of grass carp, snake and chicken bile juices. After treating with one high dose (0.6 ml) for 6 and 24 h, the levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase (ALP), blood urea nitrogen (BUN) and creatinine in the plasma of rats in the grass carp bile juice group became higher than those of the other two bile treated groups. After 3-days periodic treatment with 0.3 ml of each animal bile juice for 28 days, the levels of GOT, GPT, BUN and creatinine in the plasma of rats were significantly increased, especially the grass carp bile juice-treated rats. It appeared that the rats administered with snake and chicken bile juices for a much longer time were poisoned and had the same symptoms as those treated with grass carp bile juice.
为评估不同动物胆汁的毒性作用，选用雄性Long-Evans大鼠，经口给予不同剂量（0.03 - 0.6毫升）的草鱼胆汁、蛇胆汁和鸡胆汁。在给予一次高剂量（0.6毫升）胆汁6小时和24小时后，草鱼胆汁组大鼠血浆中的谷草转氨酶（GOT）、谷丙转氨酶（GPT）、碱性磷酸酶（ALP）、血尿素氮（BUN）和肌酐水平高于其他两组胆汁处理组。在用0.3毫升每种动物胆汁进行为期28天的定期处理后，大鼠血浆中的GOT、GPT、BUN和肌酐水平显著升高，尤其是草鱼胆汁处理组的大鼠。似乎长时间给予蛇胆汁和鸡胆汁的大鼠也出现中毒症状，且与草鱼胆汁处理组大鼠的症状相同。
