Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
Evid Based Complement Alternat Med. 2012;2012:257374. doi: 10.1155/2012/257374. Epub 2012 Feb 27.
The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. root (EEM) in normal and diabetic mice. After induction of diabetes with streptozotocin, both normal and diabetic mice were singly or repeatedly for 28 days administrated with EEM at doses of 2, 4, 8 g/kg, respectively. Before induction of diabetes, mice were administrated with EEM at doses of 2, 4, 8 g/kg for 14 days and were injected with streptozotocin and continued on EEM administration for another 28 days. Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice. Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice. Single administration with EEM had no hypoglycemic and hypolipidemic effects on normal and diabetic mice. These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.
本研究探讨了白花曼陀罗根的乙醇提取物（EEM）在正常和糖尿病小鼠中的胰岛素敏感性、降血糖和降血脂活性。用链脲佐菌素诱导糖尿病后，正常和糖尿病小鼠分别单次或重复 28 天给予 EEM，剂量分别为 2、4、8 g/kg。在诱导糖尿病之前，小鼠给予 EEM，剂量为 2、4、8 g/kg，共 14 天，并注射链脲佐菌素，继续给予 EEM 治疗 28 天。在诱导糖尿病前后，重复给予 4、8 g/kg EEM 可持续降低血糖水平，降低血清胰岛素水平，改善胰岛素敏感指数，降低血清总胆固醇、甘油三酯水平和肝脏及骨骼肌中的甘油三酯含量，并增加这些组织中的糖原含量；但重复给予 EEM 对正常小鼠的这些指标没有影响。EEM（4、8 g/kg）单次给药在正常和糖尿病小鼠的口服葡萄糖耐量试验中显示出降血糖作用。EEM 单次给药对正常和糖尿病小鼠均无降血糖和降血脂作用。这些结果表明，EEM 对糖尿病具有潜在的胰岛素敏感性、降血糖和降血脂作用。
