McManus K, McGuigan J
Northern Ireland Regional Thoracic Surgical Department, Royal Victoria Hospital, Belfast, Northern Ireland.
Ulster Med J. 1994 Oct;63(2):127-36.
In the late 1970's the options for treatment of oesophageal cancer were limited. When cure was thought possible, resection was performed by the Ivor Lewis or oesophagogastrectomy techniques. Mortality was high, local recurrence rates disappointing, and long-term survival poor. For those patients whose tumours could not be resected, palliative intubation required open operation with high morbidity, and gave poor quality of life. In 1994, selective screening is diagnosing cancers early, more extensive resections are possible with lower mortality, and fewer local recurrences. Adjuvant therapy is increasing the operability rates. Gradually the facade of poor prognosis is being etched away, so that more patients are being given better quality of life, and cure is a distinct possibility. Palliation can be achieved endoscopically by dilatation, intubation or laser ablation combined with local external beam radiation. Mortality for palliative procedures is now considerably reduced.
20世纪70年代末,食管癌的治疗选择有限。当认为有可能治愈时,通过艾弗·刘易斯手术或食管胃切除术进行切除。死亡率很高,局部复发率令人失望,长期生存率很低。对于那些肿瘤无法切除的患者,姑息性插管需要进行开放性手术,发病率很高,且生活质量很差。1994年,选择性筛查能够早期诊断癌症,更广泛的切除成为可能,死亡率更低,局部复发更少。辅助治疗正在提高可手术率。逐渐地,预后不良的表象正在被消除,因此更多患者的生活质量得到改善,治愈也成为一种明显的可能性。姑息治疗可以通过扩张、插管或激光消融结合局部外照射在内镜下实现。现在姑息治疗的死亡率已大幅降低。