慢性免疫性血小板减少性紫癜患者的循环血小板生成素水平

Circulating thrombopoietin level in chronic immune thrombocytopenic purpura.

作者信息

Kosugi S, Kurata Y, Tomiyama Y, Tahara T, Kato T, Tadokoro S, Shiraga M, Honda S, Kanakura Y, Matsuzawa Y

机构信息

Second Department of Internal Medicine, Osaka University Medical School, Japan.

出版信息

Br J Haematol. 1996 Jun;93(3):704-6. doi: 10.1046/j.1365-2141.1996.d01-1702.x.

DOI:10.1046/j.1365-2141.1996.d01-1702.x

PMID:8652398

Abstract

The circulating thrombopoietin (TPO) level in 43 patients with chronic immune thrombocytopenic purpura (ITP) was examined by an ELISA system. The TPO level (mean +/- SD) in ITP patients was mildly elevated (1.86 +/- 1.17 fmol/ml) compared to that in normal subjects (0.76 +/- 0.21), and was within the normal range in 30% of ITP patients. In contrast, the TPO level in patients with aplastic anaemia was very high, 12.35 +/- 6.42 fmol/ml. There was no correlation between TPO level and platelet count in ITP patients. Splenectomy was performed in two ITP patients, after which platelet counts increased to normal levels and TPO levels showed a transient increase. These data suggest that reactive TPO production against thrombocytopenia in ITP is small when compared to that in aplastic anaemia. Relative endogenous TPO deficiency may play some role in the pathophysiology of thrombocytopenia in ITP patients.

摘要

采用酶联免疫吸附测定（ELISA）系统检测了43例慢性免疫性血小板减少性紫癜（ITP）患者的循环血小板生成素（TPO）水平。与正常受试者（0.76±0.21）相比，ITP患者的TPO水平（均值±标准差）轻度升高（1.86±1.17 fmol/ml），且30%的ITP患者TPO水平在正常范围内。相比之下，再生障碍性贫血患者的TPO水平非常高，为12.35±6.42 fmol/ml。ITP患者的TPO水平与血小板计数之间无相关性。对2例ITP患者实施了脾切除术，术后血小板计数升至正常水平，TPO水平出现短暂升高。这些数据表明，与再生障碍性贫血相比，ITP中针对血小板减少的反应性TPO生成较少。相对内源性TPO缺乏可能在ITP患者血小板减少的病理生理过程中起一定作用。