Njunda A L, Oyerinde J P
Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Nigeria.
West Afr J Med. 1996 Jan-Mar;15(1):24-30.
Aspects of the biology of Salmonella typhi in concurrent infection with Schistosoma mansoni in mice was studied. 0.2ml of 1 x 10(6) per S. tyhi was inoculated intraperitoneally into mice harbouring different developmental stages of S. mansoni. The rate of bacterial growth, the distribution and duration of the bacterial infection in mice and in Schistosome, as well as the drug (Chloramphenicol) response of the bacteria were studied. S. typhi was cultured more frequently in schistosome-infected mice than in mice that were not infected with schistosme (P < 0.05). The bacterial growth rate was more rapid in mice infected with older schistosomes. Similarly the bacteria persisted much longer in mice infected with adult S. mansoni (8 weeks old) than those infected with younger (2 and 4 weeks old) schistosomes. The results of treatment of S. typhi infected mice previously infected with schistosomes of different ages made us to conclude that adult schistosomes (8 weeks old) are more relevant in the modified response to treatment of patients with S. typhi infection with concurrent Schistosoma mansoni infection.
研究了小鼠同时感染曼氏血吸虫时伤寒沙门氏菌的生物学特性。将每0.2毫升含1×10⁶个伤寒沙门氏菌的菌液腹腔注射到感染了不同发育阶段曼氏血吸虫的小鼠体内。研究了细菌的生长速率、在小鼠和血吸虫体内的分布及感染持续时间，以及细菌对药物（氯霉素）的反应。与未感染血吸虫的小鼠相比，伤寒沙门氏菌在感染血吸虫的小鼠体内培养更为频繁（P<0.05）。在感染较成熟血吸虫的小鼠中细菌生长速率更快。同样，与感染较年轻（2周龄和4周龄）血吸虫的小鼠相比，细菌在感染成年曼氏血吸虫（8周龄）的小鼠体内持续存在的时间长得多。对先前感染了不同年龄血吸虫的伤寒沙门氏菌感染小鼠进行治疗的结果使我们得出结论，成年血吸虫（8周龄）在同时感染曼氏血吸虫的伤寒沙门氏菌感染患者对治疗的反应改变中更为相关。
