特应性皮炎患者和健康受试者对屋尘螨的接触性过敏

Contact allergy to Dermatophagoides in atopic dermatitis patients and healthy subjects.

作者信息

Manzini B M, Motolese A, Donini M, Seidenari S

机构信息

Department of Dermatology, University of Modena, Italy.

出版信息

Contact Dermatitis. 1995 Oct;33(4):243-6. doi: 10.1111/j.1600-0536.1995.tb00475.x.

DOI:10.1111/j.1600-0536.1995.tb00475.x

PMID:8654075

Abstract

To compare different house-dust-mite-derived allergenic materials and to correlate the presence of IgE to Dermatophagoides with patch test results, 313 atopic dermatitis (AD) patients and 100 healthy volunteers (HV) underwent patch tests with: Dermatophagoides pteronyssinus (DPT) lyophilized purified alpha fraction in buffered saline/glycerol 50% and/or in petrolatum (Bayropharm); 50% DPT and 50% Dermatophagoides farinae (DF) whole bodies in petrolatum and petrolatum oil (Allergopharma-Bracco); DPT and DF whole bodies in petrolatum and petrolatum oil (Lofarma). We found 39% positive reactions among AD subjects and 13% in HV. The presence of serum-specific IgE did not influence the patch test results. 38% of AD patch-test-positive patients and 4 of 13 HV, respectively, showed a positive prick test and/or RAST to Dermatophagoides. Similar sensitization rates were observed with the allergenic material from Bayropharm (54% positives) and Allergopharma-Bracco (51% positives), whereas the preparations from Lofarma gave a 20% response rate.

摘要

为比较不同的屋尘螨衍生变应原物质，并将针对粉尘螨的IgE的存在情况与斑贴试验结果相关联，313例特应性皮炎（AD）患者和100名健康志愿者（HV）接受了以下斑贴试验：粉尘螨（DPT）冻干纯化α组分，置于50%缓冲盐水/甘油中及/或凡士林（Bayropharm）中；50% DPT和50%粗脚粉螨（DF）全虫体，置于凡士林和凡士林油中（Allergopharma-Bracco）；DPT和DF全虫体，置于凡士林和凡士林油中（Lofarma）。我们发现AD受试者中有39%出现阳性反应，HV中有13%出现阳性反应。血清特异性IgE的存在并不影响斑贴试验结果。分别有38%的AD斑贴试验阳性患者和13名HV中的4名，对粉尘螨的点刺试验和/或放射性变应原吸附试验（RAST）呈阳性。使用Bayropharm的变应原物质（54%阳性）和Allergopharma-Bracco的变应原物质（51%阳性）观察到相似的致敏率，而Lofarma的制剂的反应率为20%。