人类ST2基因定位于2号染色体q11.2。
Assignment of the human ST2 gene to chromosome 2 at q11.2.
作者信息
Tominaga S, Inazawa J, Tsuji S
机构信息
Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.
出版信息
Hum Genet. 1996 May;97(5):561-3. doi: 10.1007/BF02281860.
PMID:8655130
Abstract
The human St2 locus has been assigned to chromosome 2, using a human ST2 cDNA clone, by a human/rodent somatic cel hybrid mapping panel. The St2 locus has also been mapped to chromosome 2q11.2, using a human ST2 genomic DNA clone, by in situ hybridization. The locus is very tightly linked to the Il-1r1 locus. Together with the structural similarity of ST2 to IL-1RI, these data suggest functional relationships between these two genes.
摘要
利用人/啮齿动物体细胞杂交定位板，通过一个人ST2 cDNA克隆，已将人类St2基因座定位于2号染色体。通过原位杂交，利用一个人ST2基因组DNA克隆，也已将St2基因座定位于2q11.2染色体。该基因座与Il-1r1基因座紧密连锁。连同ST2与IL-1RI的结构相似性，这些数据表明这两个基因之间存在功能关系。
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