Marasini B, Pipia C, DeValle G, Crosignani A, Petroni L, Cugno M, Zeni S, Bruno S, Bassani C
Department of Rheumatology, University of Milan, Italy.
Int J Microcirc Clin Exp. 1995 Mar-Apr;15(2):75-9. doi: 10.1159/000178953.
Experimental and clinical observation suggest that patients with primary biliary cirrhosis (PBC) have endothelial dysfunction. Postischemic digital blood flow, nailfold capillaroscopy, von Willebrand factor (vWf) and tissue-type plasminogen activator (t-PA) plasma levels were examined in 59 PBC patients. Forty-six subjects (15 with liver diseases other than PBC, 11 hypercholesterolemics, 20 healthy subjects) served as controls. PBC versus healthy controls (209.8 +/- 1.4% and 16.54 +/- 1.44 ng/ml vs. 120.2 +/- 1.4% and 9.91 +/- 1.49 ng/ml; p<0.001) and related to bilirubin (r = 0.38, p<0.02; r = 0.47, p<0.0005, respectively). vWf was also increased in other liver diseases (249.9 +/- 1.7%; p<0.001) and related to bilirubin (r = 0.59, p<0.05). Postischemic finger blood flow negatively correlated with vWf(p<0.05 or less). Our data indicate that PBC patients have microvascular disease. Whether vessels other than those of the fingers were involved remained unclear. vWf and t-PA might reflect a dysfunction of teh hepatic vascular endothelium.
实验和临床观察表明，原发性胆汁性肝硬化（PBC）患者存在内皮功能障碍。对59例PBC患者的缺血后指端血流、甲襞毛细血管镜检查、血管性血友病因子（vWf）和组织型纤溶酶原激活剂（t-PA）血浆水平进行了检测。46名受试者（15例患有PBC以外的肝脏疾病、11例高胆固醇血症患者、20例健康受试者）作为对照。PBC患者与健康对照者相比（分别为209.8±1.4%和16.54±1.44 ng/ml，对比120.2±1.4%和9.91±1.49 ng/ml；p<0.001），且与胆红素相关（r = 0.38，p<0.02；r = 0.47，p<0.0005）。vWf在其他肝脏疾病中也升高（249.9±1.7%；p<0.001），并与胆红素相关（r = 0.59，p<0.05）。缺血后指端血流与vWf呈负相关（p<0.05或更低）。我们的数据表明，PBC患者存在微血管疾病。手指以外的血管是否受累尚不清楚。vWf和t-PA可能反映了肝血管内皮功能障碍。
