Rajewsky K
Institute of Genetics, University of Cologne, Weyertal, Germany.
Nature. 1996 Jun 27;381(6585):751-8. doi: 10.1038/381751a0.
Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of ordered gene rearrangements which must be successfully performed if the cell is to survive. A second selection process occurs during immune responses in which a new antibody repertoire is generated through somatic hypermutation. Here only mutants binding antigen with high affinity survive to become memory cells. Cells expressing autoreactive receptors are counter-selected at both stages. This stringent positive and negative selection allows the generation and diversification of cells while rigorously controlling their specificity.
每个产生抗体的B细胞都会产生具有独特特异性的抗体，这反映了一系列有序的基因重排，如果细胞要存活，这些重排必须成功进行。在免疫反应过程中会发生第二个选择过程，其中通过体细胞超突变产生新的抗体库。在这里，只有那些以高亲和力结合抗原的突变体才能存活下来成为记忆细胞。在两个阶段都会对表达自身反应性受体的细胞进行反向选择。这种严格的正向和负向选择允许细胞的产生和多样化，同时严格控制它们的特异性。
