Bidzińska B, Jedrzejuk D
Katedra i Klinika Endokrynologii Akademii Medycznej we Wrocławiu.
Postepy Hig Med Dosw. 1995;49(4):523-30.
Gonadal steroids and beta-endorphin (beta-EP) (and probably other - EOP endogenous opioid peptides) play a role of the pivotal hormones involved in integration of several neurophysiological mechanisms. The reproductive system could be disturbed at hypothalamic level by interference of beta-EP and GnRH secretion and/or at pituitary level with response of gonadotropes to GnRH. Gonadal steroids, through a feedback mechanism, may exert similar effect on hypothalamus and/or pituitary. The action of EOP on the hypothalamo-pituitary-gonadal axis may be influenced by physiological and pathological changes in gonadal steroids during puberty, menstrual cycle in females, menopause, in case of idiopathic delayed puberty, in patients with gonadal dysgenesis or after castration. EOP seems to be "gonadostat" system that have a key role in the transmission of gonadal feedback signals to the brain.
性腺类固醇和β-内啡肽（β-EP）（可能还有其他内源性阿片样肽-EOP）在整合多种神经生理机制中发挥关键激素的作用。β-EP和促性腺激素释放激素（GnRH）分泌的干扰可能会在下丘脑水平扰乱生殖系统，和/或在垂体水平影响促性腺细胞对GnRH的反应。性腺类固醇通过反馈机制，可能会对下丘脑和/或垂体产生类似的影响。青春期、女性月经周期、绝经、特发性青春期延迟、性腺发育不全患者或阉割后的患者，性腺类固醇的生理和病理变化可能会影响EOP对下丘脑-垂体-性腺轴的作用。EOP似乎是“性腺静止”系统，在将性腺反馈信号传递到大脑中起关键作用。
