Numa F, Takeda O, Nakata M, Nawata S, Tsunaga N, Hirabayashi K, Suminami Y, Kato H, Hamanaka S
Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Japan.
Tumour Biol. 1996;17(2):97-101. doi: 10.1159/000217972.
Squamous cell carcinoma (SCC) antigen, a tumor marker of squamous cell carcinoma, is also increased in several nonmalignant skin lesions, e.g. pemphigus. The aim of the present investigation was to determine if tumor necrosis factor-alpha (TNF-alpha), one of the important environmental factors, stimulated the production of SCC antigen in the normal squamous cells. The exposure of normal human epidermal keratinocytes to TNF-alpha (100 IU/ml) for 72 h greatly increased the SCC antigen production. The stimulatory effect of TNF-alpha (1,000 IU/ml) on the production of SCC antigen was also observed in the normal squamous epithelium tissue. These results would be helpful for understanding the increase of SCC antigen in several nonmalignant skin disorders.
鳞状细胞癌（SCC）抗原是鳞状细胞癌的一种肿瘤标志物，在几种非恶性皮肤病变（如天疱疮）中也会升高。本研究的目的是确定肿瘤坏死因子-α（TNF-α）这一重要环境因素之一是否会刺激正常鳞状细胞中SCC抗原的产生。正常人表皮角质形成细胞暴露于TNF-α（100 IU/ml）72小时后，SCC抗原的产生显著增加。在正常鳞状上皮组织中也观察到TNF-α（1000 IU/ml）对SCC抗原产生的刺激作用。这些结果将有助于理解几种非恶性皮肤疾病中SCC抗原升高的情况。
