Torre G C
Department of Obstetrics and Gynecology, Azienda Ospedaliera, Ospedale Santa Corona, Pietra Ligure, Italia.
Tumour Biol. 1998;19(6):517-26. doi: 10.1159/000030045.
Squamous cell carcinoma (SCC) antigen (Ag) present and expressed in normal epithelium and epithelial tissues is used primarily as tumor marker of SCC of the uterine cervix. In this review, we considered factors interfering in vitro with the collection of samples and assay procedures, benign and malignant nongynecological diseases which may be the cause of elevated serum levels of SCC Ag. Contamination with skin or saliva strongly influences SCC Ag levels. SCC Ag is elevated in several benign lesions, including pulmonary (tuberculosis, adult respiratory distress syndrome, pulmonary infiltration with eosinophilia, sarcoidosis, bronchogenic cyst) and skin (eczema, pemphigus, erythroderma epidermitis, psoriasis) diseases. Elevations are observed in SCC malignancies of the head and neck, esophagus, skin, lung, urothelium, anal canal and vulva.
鳞状细胞癌（SCC）抗原存在于正常上皮组织和上皮性组织中并在其中表达，主要用作子宫颈鳞状细胞癌的肿瘤标志物。在本综述中，我们考虑了在体外干扰样本采集和检测程序的因素、可能导致血清SCC抗原水平升高的非妇科良性和恶性疾病。皮肤或唾液污染会强烈影响SCC抗原水平。SCC抗原在一些良性病变中升高，包括肺部疾病（肺结核、成人呼吸窘迫综合征、嗜酸性粒细胞性肺浸润、结节病、支气管源性囊肿）和皮肤疾病（湿疹、天疱疮、红皮病性表皮炎、银屑病）。在头颈部、食管、皮肤、肺、尿路上皮、肛管和外阴的鳞状细胞癌恶性肿瘤中也观察到其升高。
