Shirley D M, Williams S L, Covey J F, Santos P M
Division of Otolaryngology, Southern Illinois University, Springfield, USA.
Arch Otolaryngol Head Neck Surg. 1996 Jul;122(7):785-8. doi: 10.1001/archotol.1996.01890190081018.
To compare reanastomosis and entubulation repair after transection of the peroneal nerve in rats with the use of 2 functional models: gait analysis and a tension transduction device.
Prospective, randomized, blinded control study. Each animal served as its own control. The injured site was alternated between the left and the right. Gait analysis was evaluated in a blind fashion at postoperative weeks 1, 3, 7, and 13, and the tension transduction device at week 13, for injured and uninjured legs.
Animals underwent unilateral peroneal nerve transection injury, half with entubulation and half with end-to-end reanastomosis repair.
Nerve transection was performed 6 mm proximal to the anterior tibialis muscle insertion followed by reanastomosis (epineurial suture placement to align the sectioned nerve ends) or entubulation (placement of nerve ends into a 4-mm-long sterile Silastic tube secured with 2 epineurial sutures).
Gait analysis demonstrated a poorer ankle angle in all injured legs compared with uninjured legs at each postoperative period. Ankle angles for reanastomosis were statistically better than those for entubulation at weeks 3, 7, and 13. The tension transduction device demonstrated poorer force in injured than uninjured animals at 13 weeks. Reanastomosis repair groups demonstrated no difference in force development compared with entubulation repair groups.
Reanastomosis of the transected rat peroneal nerve demonstrated improved functional return by gait analysis when compared with entubulation-repaired nerves at postoperative weeks 3, 7, and 13. Force development of injured nerve groups measured by the tension transduction device was decreased compared with control, but no difference was detected between the 2 repair methods. Further studies are needed to evaluate the possible functional benefit of reanastomosis.
使用两种功能模型（步态分析和张力传导装置）比较大鼠腓总神经横断后的再吻合术和套入修复术。
前瞻性、随机、双盲对照研究。每只动物自身作为对照。损伤部位在左右腿之间交替。在术后第1、3、7和13周以盲法评估步态分析，在第13周对受伤和未受伤的腿评估张力传导装置。
动物接受单侧腓总神经横断损伤，一半进行套入修复，一半进行端端再吻合修复。
在胫骨前肌止点近端6 mm处进行神经横断，随后进行再吻合（放置神经外膜缝线使横断的神经末端对齐）或套入修复（将神经末端放入一根4 mm长的无菌硅橡胶管中，用两根神经外膜缝线固定）。
步态分析显示，在每个术后时期，所有受伤腿的踝关节角度均比未受伤腿差。在第3、7和13周，再吻合组的踝关节角度在统计学上优于套入修复组。在13周时，张力传导装置显示受伤动物的力量比未受伤动物差。再吻合修复组与套入修复组在力量发展方面无差异。
与术后第3、7和13周的套入修复神经相比，大鼠横断腓总神经的再吻合术通过步态分析显示功能恢复更好。用张力传导装置测量的受伤神经组的力量发展与对照组相比有所下降，但两种修复方法之间未检测到差异。需要进一步研究来评估再吻合术可能的功能益处。
