Zagon I S, McLaughlin P J
Pharmacology. 1977;15(3):276-82. doi: 10.1159/000136699.
Fetal and infant rats were maternally exposed to morphine sulfate during gestation and lactation. Drug was administered twice daily by i.p. injection, with dosages gradually increased from 10 mg/kg/injection to a maintenance level of 40 mg/kg/injection. Offspring during the preweaning period had a reduction in body, brain and cerebellar weights, as well as in brain length and cerebral and cerebellar widths. Deficits persisted in young rats observed 51/2 weeks after cessation of drug exposure and in animals continuing to receive twice daily i.p. injections of 20 mg/kg/injection. These results indicate that maternal morphine treatment retards the growth of young rats and impairs brain development.
在妊娠和哺乳期，将硫酸吗啡经母体给予胎鼠和幼鼠。药物通过腹腔注射每日给药两次，剂量从10毫克/千克/注射逐渐增加至维持水平40毫克/千克/注射。断奶前期的子代体重、脑重和小脑重量降低，脑长度、大脑和小脑宽度也减小。在停止药物暴露5.5周后观察的幼鼠以及继续每日两次腹腔注射20毫克/千克/注射的动物中，这些缺陷仍然存在。这些结果表明，母体给予吗啡会延缓幼鼠生长并损害脑发育。
