Mishchuk D O, Kaplia A A
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Ukr Biokhim Zh (1999). 2002 Nov-Dec;74(6):58-64.
The ontogenetic development of the rat brain cortex Na+, K(+)-ATPase and Mg(2+)-ATPase activities under female ethanol (20% v/v) consumption in the third trimester of gestation or in postpartum period was studied. The weight characteristics (body, whole brain and cortex weight) of viable rats on the first day after birth were not affected critically by prenatal alcohol exposure. It is revealed that the delay of postnatal rat growth 10 days after birth under translactational ethanol consumption is accompanied by reliable decrease of plasma membrane Na+, K(+)-ATPase activity in comparison with control animals. The comparable decrease in activities was observed for the ouabain-sensitive and ouabain-resistant Na+, K(+)-ATPase components (isoform species). From the 20th day the differences in enzyme activity were not revealed. Mg(2+)-ATPase increases in postnatal period independent of Na+, K(+)-ATPase activity and it remains insensitive to postnatal maternal alcohol intake. It is suggested, the first ten day period of lactation is critical for ethanol effect on the developmental control of the brain Na+, K(+)-ATPase functional expression and the course of adaptive processes in the rat organism.
研究了妊娠晚期或产后雌性大鼠摄入乙醇（20% v/v）时，大鼠大脑皮层钠钾ATP酶和镁ATP酶活性的个体发育情况。出生后第一天存活大鼠的体重特征（体重、全脑和皮层重量）不受产前酒精暴露的严重影响。结果显示，与对照动物相比，哺乳期摄入乙醇的大鼠出生10天后产后生长延迟，同时伴有质膜钠钾ATP酶活性的显著降低。哇巴因敏感和哇巴因抗性的钠钾ATP酶组分（同工型）的活性也出现了类似程度的降低。从第20天起，未发现酶活性存在差异。镁ATP酶在产后阶段增加，与钠钾ATP酶活性无关，并且对产后母体酒精摄入不敏感。研究表明，哺乳期的前十天对于乙醇影响大脑钠钾ATP酶功能表达的发育控制以及大鼠机体适应性过程的进程至关重要。
