Quemener V, Bansard J Y, Delamaire M, Roth S, Havouis R, Desury D, Moulinoux J P
Laboratoire de Biologie Cellulaire, C.H.U. de Rennes, France.
Eur J Cancer. 1996 Feb;32A(2):316-21. doi: 10.1016/0959-8049(95)00584-6.
In rats with Mat Lylu prostatic carcinoma, significant changes in blood composition and red blood cell (RBC) characteristics were observed. Anaemia, characterised by a decrease in the number of RBC and the reduction of haemoglobin and the iron content in plasma, was correlated with tumour size and the accumulation of spermidine and spermine in the RBC. In large tumours, spermidine levels were increased by 8-fold over normal value. Spleen weight and splenic spermidine concentrations were enhanced in animals with tumours. After splenectomy, the rate of tumour growth decreased by 30%. It is proposed that anaemia in tumour-bearing animals is caused by enhanced RBC lysis, owing to the alteration of the rheological properties of RBC. These may be caused by the alterated surface characteristics due to polyamine accumulation. RBC lysis and high concentrations of polyamines in RBC and spleen appear, not only to favour tumour growth, but also to compromise the immunological defence mechanisms against neoplastic invasion.
在患有Mat Lylu前列腺癌的大鼠中，观察到血液成分和红细胞（RBC）特征发生了显著变化。贫血的特征是红细胞数量减少、血红蛋白降低以及血浆中铁含量降低，这与肿瘤大小以及红细胞中亚精胺和精胺的积累相关。在大肿瘤中，亚精胺水平比正常值增加了8倍。患有肿瘤的动物脾脏重量和脾脏亚精胺浓度增加。脾切除术后，肿瘤生长速率降低了30%。有人提出，荷瘤动物的贫血是由于红细胞流变学特性改变导致红细胞溶解增强所致。这可能是由于多胺积累导致表面特性改变引起的。红细胞溶解以及红细胞和脾脏中高浓度的多胺不仅似乎有利于肿瘤生长，而且还会损害针对肿瘤侵袭的免疫防御机制。
