MacDonald I A, Gould I M, Curnow J
Royal Aberdeen Children's Hospital.
Epidemiol Infect. 1996 Jun;116(3):279-84. doi: 10.1017/s0950268800052584.
A 3-year study of Escherichia coli infections in Grampian Region was conducted to ascertain the incidence, document clinical sequelae and identify at-risk groups. Approximately 30,000 stools from patients with acute diarrhoea were screened for E. coli O157, and an epidemiological questionnaire filled in for each patient whose stool was positive. Eighty-three patients were studied. The annual incidence was 6 per 100, 000. Proportionately more infections occurred in people involved in agriculture. Evidence was seen of case-to-case transmission, and contamination of a water supply. Eight cases developed haemolytic uraemic syndrome (HUS). There were 2 deaths due to HUS and 2 due to haemorrhagic colitis (HC). Symptomatic E. coli infection is relatively common in the Grampian Region, more common in the agricultural community, and is the main cause of HUS in this Region.
在格兰扁地区开展了一项为期3年的大肠杆菌感染研究，以确定发病率、记录临床后遗症并识别高危人群。对约30000例急性腹泻患者的粪便进行了大肠杆菌O157筛查，并为每例粪便检测呈阳性的患者填写了一份流行病学调查问卷。对83例患者进行了研究。年发病率为十万分之六。从事农业的人群中感染比例相对较高。发现了病例间传播及水源污染的证据。8例患者发展为溶血尿毒综合征（HUS）。有2例死于HUS，2例死于出血性结肠炎（HC）。有症状的大肠杆菌感染在格兰扁地区相对常见，在农业社区更为常见，并且是该地区HUS的主要病因。
