Gavaldà L, Porta M, Malats N, Piñol J L, Fernández E, Maguire A, Cortès I, Carrillo E, Marrugat M, Rifà J
Instituto Municipal de Investigación Médica (IMIM), Universidad Autónoma de Barcelona.
Gac Sanit. 1995 Nov-Dec;9(51):334-42. doi: 10.1016/s0213-9111(95)71258-4.
No study on mutations in the K-ras oncogene and cancer of the exocrine pancreas or cancer of the biliary system has analyzed the reliability of clinical and epidemiological information.
Agreement between patient and surrogate on factors potentially related to both tumours was evaluated within a multicentre prospective study. Interviews were personally administered to both patient and surrogate (N = 110 pairs). Agreement was examined via the simple kappa index (k), the weighted kappa index (kw), the percentage of simple agreement, and the percentages of positive and negative agreement.
Agreement for medical history was excellent (k between 0.89 and 0.76), as it was for tobacco consumption (k = 0.98). Agreement was moderate for coffee consumption (k = 0.68), frequencies of food groups (kw from 0.66 to 0.38), and consumption of alcoholic drinks (k from 0.66 to 0.32). Surrogates indicated a higher consumption of alcohol than patients.
Surrogates can be an alternative source of information when patients cannot be interviewed, but information on alcohol consumption should be treated with caution.
尚无关于K-ras癌基因与外分泌性胰腺癌或胆道系统癌症突变的研究分析临床和流行病学信息的可靠性。
在一项多中心前瞻性研究中评估了患者与其替代者之间在可能与两种肿瘤均相关的因素方面的一致性。对患者及其替代者（共110对）均进行了亲自访谈。通过简单kappa指数（k）、加权kappa指数（kw）、简单一致性百分比以及阳性和阴性一致性百分比来检验一致性。
病史方面的一致性极佳（k在0.89至0.76之间），吸烟情况的一致性也是如此（k = 0.98）。咖啡饮用情况的一致性为中等（k = 0.68），食物种类的频率（kw在0.66至0.38之间）以及酒精饮料饮用情况的一致性（k在0.66至0.32之间）。替代者报告的酒精摄入量高于患者。
当无法对患者进行访谈时，替代者可作为信息的替代来源，但关于酒精摄入量的信息应谨慎对待。
