Yang D, Morrison B D, Vandongen Y K, Singh A, Stacey M C
Fremantle Hospital, WA.
Med J Aust. 1996 Jun 17;164(12):718-20. doi: 10.5694/j.1326-5377.1996.tb122269.x.
To evaluate the frequency of malignant ulcers in patients presenting with leg ulcers.
A descriptive study from data collected between July 1988 and June 1995 from 981 patients (2448 ulcers) attending a leg ulcer clinic.
A specialised leg ulcer clinic at a tertiary teaching hospital.
43 patients with 55 malignant skin lesions.
Tissue biopsies in ulcerated lesions that suggested malignancy or were not responding to appropriate treatment.
Forty-three patients were found to have malignant lesions on the legs, giving a frequency of malignant ulcers of 4.4 per 100 leg ulcer patients, or 2.2 per 100 leg ulcers. Seventy-five per cent of the malignant ulcers were basal cell carcinoma and 25% were squamous cell carcinoma.
Malignant skin changes are common in chronic leg ulcers. A biopsy should be taken from all suspicious ulcers or ulcers that do not respond to appropriate treatment.
评估腿部溃疡患者中恶性溃疡的发生率。
一项描述性研究，数据收集于1988年7月至1995年6月期间，来自一家腿部溃疡诊所的981例患者（2448处溃疡）。
一家三级教学医院的专业腿部溃疡诊所。
43例患有55处恶性皮肤病变的患者。
对提示为恶性或对适当治疗无反应的溃疡病变进行组织活检。
发现43例患者腿部有恶性病变，恶性溃疡的发生率为每100例腿部溃疡患者中有4.4例，或每100处腿部溃疡中有2.2例。75%的恶性溃疡为基底细胞癌，25%为鳞状细胞癌。
慢性腿部溃疡中恶性皮肤改变很常见。应从所有可疑溃疡或对适当治疗无反应的溃疡处取材进行活检。
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