Grancini F, Sangermani R, Adami A, Vaglia P, Gibelli M, Maestri L
Divisione di Pediatria, Ospedale San Carlo Borromeo di Milano, Italia.
Pediatr Med Chir. 1995 Nov-Dec;17(6):519-23.
Fainting syncopal events are caused by a transient functional neuronal paralysis. Reflex syncope happens for brainstem involving mediated by peripherical afferents. Sometimes gastroesophageal reflux (GER) has been implicated in the development of obstructive apnea. Gastroesophageal reflux, despite the absence of a clinical history of vomiting and regurgitation, is observed in a significant proportion of infants presenting with ALTE (Apparent Life Threatening Event): an episode characterized by some combination of apnea, color change, marked change in muscle tone, choking or gagging. Though a cause-and-effect relationship between GER and the development of ALTE remains to be established a possible direct relationship between oesophageal acidification and the onset of alterations in cardiopulmonary function and impairment of consciousness can be hypothesized. We refer the case of two female infants that developed recurrent ALTE(s) characterized by paleness, change in muscle tone and loss of consciousness. The infants resulted affected respectively by a mild and severe gastroesophageal reflux (score: 40, > 50); in one case an episode of GER was recorded by the intraoesophageal pH-monitoring during a syncopal episode. The treatment with antiacid drugs was effectual and the infants did not present ALTE(s). The cases presented are in favour of a routine search of gastroesophageal reflux in infants presenting with one or recurrent ALTE(s). The identification of these infants will permitt to develop a correct strategy of treatment.
昏厥性晕厥事件是由短暂性功能性神经元麻痹引起的。反射性晕厥发生于涉及外周传入神经介导的脑干。有时胃食管反流(GER)与阻塞性呼吸暂停的发生有关。尽管没有呕吐和反流的临床病史,但在出现不明原因危及生命事件(ALTE)的相当一部分婴儿中观察到胃食管反流,ALTE的特征是呼吸暂停、肤色改变、肌张力明显变化、窒息或作呕等多种表现的组合。虽然GER与ALTE发生之间的因果关系尚待确立,但可以推测食管酸化与心肺功能改变及意识障碍发作之间可能存在直接关系。我们报告两例女婴病例,她们出现以面色苍白、肌张力改变和意识丧失为特征的复发性ALTE。这两名婴儿分别患有轻度和重度胃食管反流(评分:40、>50);在其中一例中,食管内pH监测在一次晕厥发作期间记录到一次GER发作。使用抗酸药物治疗有效,婴儿未再出现ALTE。所呈现的病例支持对出现一次或复发性ALTE的婴儿常规检查胃食管反流。识别这些婴儿将有助于制定正确的治疗策略。